Chad MGI Mouse Gene Detail - MGI:1096866

Symbol

Chad
Name

chondroadherin
Synonyms

SLRR4A

Feature Type

protein coding gene
IDs

MGI:1096866
NCBI Gene: 12643
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:94455873-94459953 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM
Mapping Data

8 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096866	protein coding gene	Chr11:94455873-94459953 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018962	protein coding gene	Chr11:96674666-96678745 (+)
A/J	MGP_AJ_G0018930	protein coding gene	Chr11:92799283-92803362 (+)
AKR/J	MGP_AKRJ_G0018900	protein coding gene	Chr11:95687629-95691708 (+)
BALB/cJ	MGP_BALBcJ_G0018903	protein coding gene	Chr11:93250238-93254317 (+)
C3H/HeJ	MGP_C3HHeJ_G0018717	protein coding gene	Chr11:95766566-95770645 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019355	protein coding gene	Chr11:99678316-99682396 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016986	protein coding gene	Chr11:90293108-90297206 (+)
CAST/EiJ	MGP_CASTEiJ_G0018272	protein coding gene	Chr11:96486609-96490686 (+)
CBA/J	MGP_CBAJ_G0018688	protein coding gene	Chr11:103829722-103833801 (+)
DBA/2J	MGP_DBA2J_G0018796	protein coding gene	Chr11:92377872-92381952 (+)
FVB/NJ	MGP_FVBNJ_G0018785	protein coding gene	Chr11:91796886-91804429 (+)
LP/J	MGP_LPJ_G0018866	protein coding gene	Chr11:97213027-97217106 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018812	protein coding gene	Chr11:103838104-103842183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019395	protein coding gene	Chr11:95914298-95918378 (+)
PWK/PhJ	MGP_PWKPhJ_G0018042	protein coding gene	Chr11:93316905-93320987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017832	protein coding gene	Chr11:95577958-95582048 (+)
WSB/EiJ	MGP_WSBEiJ_G0018321	protein coding gene	Chr11:95799911-95803989 (+)

Human Ortholog

CHAD, chondroadherin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHAD, chondroadherin
Synonyms

SLRR4A
Links

HGNC:1909

NCBI Gene ID: 1101

neXtProt AC: NX_O15335

UniProt: O15335
Chr Location

17q21.33; chr17:50464496-50468906 (-) GRCh38

MGI Vertebrate Homology

Chad stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHAD
Gene Tree

Chad

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Genomic Mutations

4 involving Chad
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit widened epiphyseal growth plate, abnormal tracbecular and cortical bone morphology and lower femoral neck failure load and tibial strength.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

39
cDNA Data

13
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN chad

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS25260.1

Ensembl

ENSMUSG00000039084 (Evidence)
NCBI Gene

12643

			Length	Strain/Species	Flank
genomic	12643	NCBI Gene Model \| MGI Sequence Detail	4081	C57BL/6J	± kb
transcript	NM_007689	RefSeq \| MGI Sequence Detail	1697	ZRU/MplStud
polypeptide	O55226	UniProt \| EBI \| MGI Sequence Detail	358	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005400 chondroadherin

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

IPR050328 Multifunctional Developmental and Immune Receptor
GlyGen

O55226 1 site

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All nucleic 16

Genomic 1

cDNA 13

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 8

Diseases 1

Gene Ontology 3

Phenotypes 8
Earliest

J:42830 Landgren C, et al., The mouse chondroadherin gene: characterization and chromosomal localization. Genomics. 1998 Jan 1;47(1):84-91
Latest

J:321577 Yin W, et al., An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea. Development. 2022 Feb 1;149(3):dev199804

TSS for Chad:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104209	Chr11:94455695-94455712 (+)	-169 bp
Tssr104210	Chr11:94455865-94455882 (+)	1 bp
Tssr104211	Chr11:94456241-94456269 (+)	382 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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