Cxcl5 MGI Mouse Gene Detail - MGI:1096868 - C-X-C motif chemokine ligand 5

Symbol

Cxcl5
Name

C-X-C motif chemokine ligand 5
Synonyms

AMCF-II, Cxcl6, ENA-78, GCP-2, granulocyte chemotactic protein-2, LIX, Scyb5, Scyb6

Feature Type

protein coding gene
IDs

MGI:1096868
NCBI Gene: 20311
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:90907219-90909483 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM
Mapping Data

8 experiments

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096868	protein coding gene	Chr5:90907157-90909484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029726	protein coding gene	Chr5:91850283-91852533 (+)
A/J	MGP_AJ_G0029692	protein coding gene	Chr5:88223784-88226183 (+)
AKR/J	MGP_AKRJ_G0029638	protein coding gene	Chr5:91086426-91088572 (+)
BALB/cJ	MGP_BALBcJ_G0029702	protein coding gene	Chr5:89125105-89127227 (+)
C3H/HeJ	MGP_C3HHeJ_G0029425	protein coding gene	Chr5:91505070-91507190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030156	protein coding gene	Chr5:95522297-95524527 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027392	protein coding gene	Chr5:83928561-83930652 (+)
CAST/EiJ	MGP_CASTEiJ_G0028835	protein coding gene	Chr5:90876043-90879951 (+)
CBA/J	MGP_CBAJ_G0029395	protein coding gene	Chr5:98792609-98794729 (+)
DBA/2J	MGP_DBA2J_G0029539	protein coding gene	Chr5:88298928-88301002 (+)
FVB/NJ	MGP_FVBNJ_G0029498	protein coding gene	Chr5:87158858-87160980 (+)
LP/J	MGP_LPJ_G0029627	protein coding gene	Chr5:92228935-92231167 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029527	protein coding gene	Chr5:103777809-103779925 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030190	protein coding gene	Chr5:90626761-90629808 (+)
PWK/PhJ	MGP_PWKPhJ_G0028554	protein coding gene	Chr5:87357431-87359706 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028389	protein coding gene	Chr5:90045694-90047735 (+)
WSB/EiJ	MGP_WSBEiJ_G0028914	protein coding gene	Chr5:91086421-91088567 (+)

Human Ortholog

CXCL5, C-X-C motif chemokine ligand 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCL5, C-X-C motif chemokine ligand 5
Synonyms

ENA-78, SCYB5
Links

HGNC:10642

NCBI Gene ID: 6374

neXtProt AC: NX_P42830

UniProt: P42830
Chr Location

4q13.3; chr4:73995642-73998677 (-) GRCh38

Human Ortholog

CXCL6, C-X-C motif chemokine ligand 6
Synonyms

CKA-3, GCP-2, GCP2, SCYB6
Links

HGNC:10643

NCBI Gene ID: 6372

neXtProt AC: NX_P80162

UniProt: P80162
Chr Location

4q13.3; chr4:73836640-73849064 (+) GRCh38

MGI Vertebrate Homology

Cxcl5 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CXCL5, CXCL6
Gene Tree

Cxcl5

Diseases

1 with human CXCL5 associations

				Human Disease	Mouse Models
				idiopathic pulmonary fibrosis IDs idiopathic pulmonary fibrosis DOID:0050156 EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 UMLS_CUI:C1800706

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

6
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Cxcl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased chemokine scavenging, decrease suscetibility to bacterial infection, and altered neutrophil physiology.

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

51
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS19414.1

Ensembl

ENSMUSG00000029371 (Evidence)
NCBI Gene

20311

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029371	Ensembl Gene Model \| MGI Sequence Detail	2265	C57BL/6J	± kb
transcript	ENSMUST00000031318	Ensembl \| MGI Sequence Detail	1575	Not Applicable
polypeptide	ENSMUSP00000031318	Ensembl \| MGI Sequence Detail	132	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006071 C-X-C motif chemokine 5

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain

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All nucleic 14

cDNA 11

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1352761

Summaries

All 82

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cxcl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47178	Chr5:90907208-90907226 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24