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Eef1a1 Gene Detail
Summary
  • Symbol
    Eef1a1
  • Name
    eukaryotic translation elongation factor 1 alpha 1
  • Synonyms
    MGC:18758, MGC:27859, MGC:7551, MGC:8115, MGC:8209
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096881
    NCBI Gene: 13627
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78385735-78389006 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096881
 protein coding gene Chr9:78385731-78396433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024042
 protein coding gene Chr17:81685916-81687200 (-)
A/J MGP_AJ_G0023999
 protein coding gene Chr17:79187113-79187872 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0024001
 protein coding gene Chr17:79050282-79051041 (-)
C3H/HeJ MGP_C3HHeJ_G0023765
 protein coding gene Chr17:81292171-81292930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035563
 protein coding gene Chr9:81127025-81128406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014548
 protein coding gene Chr1:120196743-120197775 (-)
CAST/EiJ MGP_CASTEiJ_G0023245
 protein coding gene Chr17:81895527-81896289 (-)
CBA/J MGP_CBAJ_G0023739
 protein coding gene Chr17:88198147-88199352 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0023834
 protein coding gene Chr17:77222885-77223644 (-)
LP/J MGP_LPJ_G0023951
 protein coding gene Chr17:82534023-82536477 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0024490
 protein coding gene Chr17:80865420-80866264 (-)
PWK/PhJ MGP_PWKPhJ_G0022991
 protein coding gene Chr17:77199363-77200559 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022802
 protein coding gene Chr17:77658452-77659210 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    EEF1A1, eukaryotic translation elongation factor 1 alpha 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF1A1, eukaryotic translation elongation factor 1 alpha 1
  • Synonyms
    CCS-3, CCS3, EE1A1, EEF-1, EEF1A, eEF1A-1, EF1A, EF1A1, EF1alpha1, EF-Tu, GRAF-1EF, LENG7, PTI1
  • Links
    NCBI Gene ID: 1915
    neXtProt AC: NX_P68104
    UniProt: P68104

  • Chr Location
    6q13; chr6:73489308-73525587 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    36
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Eef1a1
  • Find Mice (IMSR)
    60 strains or lines available
Mice homozygous for a knockdown allele exhibit impaired conditioned safety response to withdrawal of cued stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    72
  • cDNA Data
    58
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13627 NCBI Gene Model | MGI Sequence Detail 3272 C57BL/6J ±  kb
transcript NM_010106 RefSeq | MGI Sequence Detail 1790 Not Specified  
polypeptide P10126 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000006903 elongation factor 1-alpha 1
    (term hierarchy)
  • EC
    3.6.5.-
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR050100 Translation factor GTPase superfamily members
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
  • GlyGen
    P10126 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 61
    cDNA 59
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 116
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 14
    Phenotypes 49
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:352924 Sun H, et al., Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4. Cell Metab. 2023 Jun 6;35(6):1022-1037.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory