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Ptgis Gene Detail
Summary
  • Symbol
    Ptgis
  • Name
    prostaglandin I2 (prostacyclin) synthase
  • Synonyms
    Cyp8a1, Pgi2, Pgis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097156
    NCBI Gene: 19223
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167033725-167082524 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.22 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097156
 protein coding gene Chr2:167033725-167095069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026910
 protein coding gene Chr2:172901471-172956591 (-)
A/J MGP_AJ_G0026877
 protein coding gene Chr2:165801471-165851113 (-)
AKR/J MGP_AKRJ_G0026848
 protein coding gene Chr2:170737900-170788978 (-)
BALB/cJ MGP_BALBcJ_G0026886
 protein coding gene Chr2:166145265-166200480 (-)
C3H/HeJ MGP_C3HHeJ_G0026628
 protein coding gene Chr2:171105602-171158004 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027333
 protein coding gene Chr2:177933509-177994590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024704
 protein coding gene Chr2:159126184-159175387 (-)
CAST/EiJ MGP_CASTEiJ_G0026086
 protein coding gene Chr2:171570683-171622671 (-)
CBA/J MGP_CBAJ_G0026605
 protein coding gene Chr2:184449024-184507817 (-)
DBA/2J MGP_DBA2J_G0026743
 protein coding gene Chr2:164916537-164964890 (-)
FVB/NJ MGP_FVBNJ_G0026709
 protein coding gene Chr2:163427594-163481192 (-)
LP/J MGP_LPJ_G0026844
 protein coding gene Chr2:172924571-172977797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026728
 protein coding gene Chr2:187848293-187908732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027390
 protein coding gene Chr2:170643551-170698961 (-)
PWK/PhJ MGP_PWKPhJ_G0025823
 protein coding gene Chr2:164572917-164623035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025624
 protein coding gene Chr2:169593163-169644755 (-)
WSB/EiJ MGP_WSBEiJ_G0026159
 protein coding gene Chr2:171551826-171612572 (-)



Homology
more
  • Human Ortholog
    PTGIS, prostaglandin I2 synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGIS, prostaglandin I2 synthase
  • Synonyms
    CYP8, CYP8A1, PGIS, PTGI
  • Links
    NCBI Gene ID: 5740
    neXtProt AC: NX_Q16647
    UniProt: Q16647

  • Chr Location
    20q13.13; chr20:49503874-49568137 (-)  GRCh38
Human Diseases
more
  • Diseases
    12 with human PTGIS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased blood urea nitrogen and creatinine levels, thickening of the aorta with age, mildly increased blood pressure, and kidney abnormalities including cysts, fibrosis, necrosis, and renal vascular congestion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    928
  • Tissues
    123
  • cDNA Data
    54
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017969 Ensembl Gene Model | MGI Sequence Detail 48800 C57BL/6J ±  kb
    transcript ENSMUST00000088041 Ensembl | MGI Sequence Detail 1711 Not Applicable  
    polypeptide ENSMUSP00000085357 Ensembl | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 54
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:41092 Kuwamoto S, et al., Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. FEBS Lett. 1997 Jun 9;409(2):242-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory