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Nrg3 Gene Detail
Summary
  • Symbol
    Nrg3
  • Name
    neuregulin 3
  • Synonyms
    ska
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097165
    NCBI Gene: 18183
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:38090909-39195045 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.18 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34022 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097165
 protein coding gene Chr14:38086093-39195045 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021190
 protein coding gene Chr14:31903339-33070188 (-)
A/J MGP_AJ_G0021138
 protein coding gene Chr14:30608850-31718942 (-)
AKR/J MGP_AKRJ_G0021115
 protein coding gene Chr14:31948478-33086278 (-)
BALB/cJ MGP_BALBcJ_G0021142
 protein coding gene Chr14:30835531-31965474 (-)
C3H/HeJ MGP_C3HHeJ_G0020925
 protein coding gene Chr14:31861442-33021240 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021574
 protein coding gene Chr14:33077655-34289805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019136
 protein coding gene Chr14:30458104-31553367 (-)
CAST/EiJ MGP_CASTEiJ_G0020450
 protein coding gene Chr14:31715318-32853926 (-)
CBA/J MGP_CBAJ_G0020891
 protein coding gene Chr14:34301815-35573286 (-)
DBA/2J MGP_DBA2J_G0021014
 protein coding gene Chr14:30618956-31737314 (-)
FVB/NJ MGP_FVBNJ_G0020998
 protein coding gene Chr14:30594737-31686593 (-)
LP/J MGP_LPJ_G0021083
 protein coding gene Chr14:32161881-33292298 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021024
 protein coding gene Chr14:33625461-35011720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021607
 protein coding gene Chr14:31782131-32941645 (-)
PWK/PhJ MGP_PWKPhJ_G0020198
 protein coding gene Chr14:30148964-31259831 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020022
 protein coding gene Chr14:31381619-32543216 (-)
WSB/EiJ MGP_WSBEiJ_G0020505
 protein coding gene Chr14:31852316-33016330 (-)



Homology
more
  • Human Ortholog
    NRG3, neuregulin 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG3, neuregulin 3
  • Synonyms
    HRG3, pro-NRG3
  • Links
    NCBI Gene ID: 10718
    neXtProt AC: NX_P56975
    UniProt: P56975

  • Chr Location
    10q23.1; chr10:81875194-82987179 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrg3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal, genetic background specific, mammary gland development. Male mice homozygous for a knock-out allele show novelty-induced hyperactivity, decreased prepulse inhibition, and impaired cued conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    63
  • cDNA Data
    8
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041014 Ensembl Gene Model | MGI Sequence Detail 1104137 C57BL/6J ±  kb
    transcript ENSMUST00000166968 Ensembl | MGI Sequence Detail 4011 Not Applicable  
    polypeptide ENSMUSP00000136884 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 9
      Primer pair 3
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1354957
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:42826 Zhang D, et al., Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7
    • Latest
      J:334091 Zhang X, et al., Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory