Kng1 MGI Mouse Gene Detail - MGI:1097705

Symbol

Kng1
Name

kininogen 1
Synonyms

H-kininigen, L-kininogen

Feature Type

protein coding gene
IDs

MGI:1097705
NCBI Gene: 16644
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr16:22876970-22900828 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 13.88 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

788 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1097705	protein coding gene	Chr16:22876615-22900828 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022677	protein coding gene	Chr16:20606275-20632317 (+)
A/J	MGP_AJ_G0022639	protein coding gene	Chr16:19601817-19657886 (+)
AKR/J	MGP_AKRJ_G0022613	protein coding gene	Chr16:20455588-20489272 (+)
BALB/cJ	MGP_BALBcJ_G0022644	protein coding gene	Chr16:19802126-19841078 (+)
C3H/HeJ	MGP_C3HHeJ_G0022408	protein coding gene	Chr16:20548109-20607706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023093	protein coding gene	Chr16:21076131-21118014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020611	protein coding gene	Chr16:20260293-20286114 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022379	protein coding gene	Chr16:21930765-21979774 (+)
DBA/2J	MGP_DBA2J_G0022511	protein coding gene	Chr16:19566841-19607793 (+)
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0023105	protein coding gene	Chr16:20383022-20423210 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0021507	protein coding gene	Chr16:20126393-20150010 (+)
WSB/EiJ	MGP_WSBEiJ_G0021981	protein coding gene	Chr16:20346086-20382708 (+)

Human Ortholog

KNG1, kininogen 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KNG1, kininogen 1
Synonyms

BDK, BK, HAE6, HK, HMWK, KNG
Links

HGNC:6383

NCBI Gene ID: 3827

neXtProt AC: NX_P01042

UniProt: P01042
Chr Location

3q27.3; chr3:186717348-186744410 (+) GRCh38

MGI Vertebrate Homology

Kng1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: KNG1
Gene Tree

Kng1

Diseases

2 with human KNG1 associations

				Human Disease	Mouse Models
				hereditary angioedema IDs hereditary angioedema DOID:14735 MESH:D054179 NCI:C84758 OMIM:PS106100 ORDO:91378 UMLS_CUI:C0019243
				high molecular weight kininogen deficiency IDs high molecular weight kininogen deficiency DOID:0111676 MESH:C537060 NCI:C98946 OMIM:228960 ORDO:483 UMLS_CUI:C0272340

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Gene trapped

6
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury.

less

All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

205
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kng1

less

All Sequences

49
RefSeq

12
UniProt

4
CCDS

CCDS28073.1, CCDS49803.1, CCDS49804.1

Ensembl

ENSMUSG00000022875 (Evidence)
NCBI Gene

16644

			Length	Strain/Species	Flank
genomic	16644	NCBI Gene Model \| MGI Sequence Detail	23859	C57BL/6J	± kb
transcript	NM_001102411	RefSeq \| MGI Sequence Detail	2299	Not Specified
polypeptide	O08677	UniProt \| EBI \| MGI Sequence Detail	661	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000009430 kininogen-1

(term hierarchy)
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR002395 HMW kininogen

IPR050735 Kininogen/Fetuin/Histidine-rich Glycoprotein

IPR027358 Kininogen-type cystatin domain

IPR018073 Proteinase inhibitor I25, cystatin, conserved site
GlyGen

O08677 5 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

less

All nucleic 206

cDNA 205

Primer pair 1

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:46848 Caubin J, et al., Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res. 1994 Oct 11;22(20):4132-8
Latest

J:357891 Ohnaka Y, et al., Bradykinin deficiency causes high blood pressure in mice. Biochem Biophys Res Commun. 2023 Nov 12;681:73-79

TSS for Kng1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137639	Chr16:22877076-22877101 (+)	119 bp
Tssr137640	Chr16:22877283-22877294 (+)	319 bp
Tssr137641	Chr16:22877329-22877352 (+)	371 bp
Tssr4822	Chr16:22879125-22879128 (+)	2,157 bp
Tssr137642	Chr16:22879135-22879143 (+)	2,169 bp
Tssr137643	Chr16:22879174-22879185 (+)	2,210 bp
Tssr137644	Chr16:22879197-22879204 (+)	2,231 bp
Tssr137645	Chr16:22880386-22880403 (+)	3,425 bp
Tssr137646	Chr16:22880865-22880872 (+)	3,899 bp
Tssr137647	Chr16:22886436-22886460 (+)	9,478 bp
Tssr137648	Chr16:22886472-22886475 (+)	9,504 bp
Tssr137649	Chr16:22888030-22888041 (+)	11,066 bp
Tssr137650	Chr16:22893468-22893502 (+)	16,515 bp
Tssr137651	Chr16:22897751-22897762 (+)	20,787 bp
Tssr137652	Chr16:22898477-22898481 (+)	21,509 bp
Tssr137653	Chr16:22898703-22898725 (+)	21,744 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24