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Rrh Gene Detail
Summary
  • Symbol
    Rrh
  • Name
    retinal pigment epithelium derived rhodopsin homolog
  • Synonyms
    Peropsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097709
    NCBI Gene: 20132
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129598057-129616236 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 59.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    793 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097709
 protein coding gene Chr3:129596837-129618140 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027873
 protein coding gene Chr3:132485432-132505314 (-)
A/J MGP_AJ_G0027831
 protein coding gene Chr3:127874823-127892169 (-)
AKR/J MGP_AKRJ_G0027796
 protein coding gene Chr3:131186193-131203554 (-)
BALB/cJ MGP_BALBcJ_G0027844
 protein coding gene Chr3:127715995-127733650 (-)
C3H/HeJ MGP_C3HHeJ_G0027573
 protein coding gene Chr3:131581411-131600314 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028288
 protein coding gene Chr3:137217811-137238706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025626
 protein coding gene Chr3:123400285-123417706 (-)
CAST/EiJ MGP_CASTEiJ_G0027030
 protein coding gene Chr3:131258488-131275935 (-)
CBA/J MGP_CBAJ_G0027549
 protein coding gene Chr3:141830313-141852718 (-)
DBA/2J MGP_DBA2J_G0027690
 protein coding gene Chr3:127066148-127085001 (-)
FVB/NJ MGP_FVBNJ_G0027657
 protein coding gene Chr3:124653311-124671523 (-)
LP/J MGP_LPJ_G0027799
 protein coding gene Chr3:133992097-134010431 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027688
 protein coding gene Chr3:149790486-149810834 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028345
 protein coding gene Chr3:130860044-130878175 (-)
PWK/PhJ MGP_PWKPhJ_G0026754
 protein coding gene Chr3:126802581-126819806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026579
 protein coding gene Chr3:128925506-128939326 (-)
WSB/EiJ MGP_WSBEiJ_G0027109
 protein coding gene Chr3:131572329-131592011 (-)



Homology
more
  • Human Ortholog
    RRH, retinal pigment epithelium-derived rhodopsin homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRH, retinal pigment epithelium-derived rhodopsin homolog
  • Links
    NCBI Gene ID: 10692
    neXtProt AC: NX_O14718
    UniProt: O14718

  • Chr Location
    4q25; chr4:109827972-109849123 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal retina morphology but show increased levels of all-trans-retinol in the retina after a photobleach and lower all-trans-retinyl esters in the retinal pigmented epithelium of dark-adapted mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    7
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028012 Ensembl Gene Model | MGI Sequence Detail 18180 C57BL/6J ±  kb
    transcript ENSMUST00000029648 Ensembl | MGI Sequence Detail 1506 Not Applicable  
    polypeptide ENSMUSP00000029648 Ensembl | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:42814 Sun H, et al., Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9893-8
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory