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Hmgb3 Gene Detail
Summary
  • Symbol
    Hmgb3
  • Name
    high mobility group box 3
  • Synonyms
    Hmg2a, Hmg4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098219
    NCBI Gene: 15354
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:70599523-70604261 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 36.92 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098219
 protein coding gene ChrX:70599523-70604282 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0035767
 protein coding gene ChrX:67463281-67467030 (+)
AKR/J MGP_AKRJ_G0035689
 protein coding gene ChrX:69248367-69250694 (+)
BALB/cJ MGP_BALBcJ_G0035754
 protein coding gene ChrX:66530496-66534784 (+)
C3H/HeJ MGP_C3HHeJ_G0035457
 protein coding gene ChrX:67725704-67729849 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036284
 protein coding gene ChrX:69256619-69262269 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034749
 protein coding gene ChrX:53120259-53122583 (+)
CBA/J MGP_CBAJ_G0035432
 protein coding gene ChrX:71187770-71193659 (+)
DBA/2J MGP_DBA2J_G0035585
 protein coding gene ChrX:66946631-66950557 (+)
FVB/NJ MGP_FVBNJ_G0035536
 protein coding gene ChrX:66315076-66318901 (+)
LP/J MGP_LPJ_G0035674
 protein coding gene ChrX:68055116-68059504 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035571
 protein coding gene ChrX:73713778-73717765 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036305
 protein coding gene ChrX:67074316-67078437 (+)
PWK/PhJ MGP_PWKPhJ_G0034449
 protein coding gene ChrX:51157212-51161990 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034891
 protein coding gene ChrX:66408147-66410473 (+)



Homology
more
  • Human Ortholog
    HMGB3, high mobility group box 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGB3, high mobility group box 3
  • Synonyms
    HMG-2a, HMG2A, HMG-4, HMG4
  • Links
    NCBI Gene ID: 3149
    neXtProt AC: NX_O15347
    UniProt: O15347

  • Chr Location
    Xq28; chrX:150980507-150990771 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HMGB3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased red cell numbers, hematocrit, and hemaglobin content, and decreased mean red cell volume and common myeloid and lymphoid progenitors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    928
  • Tissues
    175
  • cDNA Data
    172
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15354 NCBI Gene Model | MGI Sequence Detail 4739 C57BL/6J ±  kb
    transcript NM_001293623 RefSeq | MGI Sequence Detail 1776 C57BL/6  
    polypeptide O54879 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008632 high mobility group protein B3
      (term hierarchy)
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR050342 High Mobility Group Box (HMGB)
      IPR017967 HMG box A DNA-binding domain, conserved site
    • GlyGen
      O54879 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 4
      cDNA 173
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1276532
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:22350 Yuan L, et al., Rapid cDNA sequencing in combination with RNA expression studies in mice identifies a large number of male germ cell-specific sequence tags. Biol Reprod. 1995 Jan;52(1):131-8
    • Latest
      J:342644 Tscherner AK, et al., Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes. Biol Reprod. 2023 Nov 15;109(5):601-617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory