Kif11 MGI Mouse Gene Detail - MGI:1098231

Symbol

Kif11
Name

kinesin family member 11
Synonyms

Eg5, Kifl1, Knsl1

Feature Type

protein coding gene
IDs

MGI:1098231
NCBI Gene: 16551
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:37364851-37410307 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.27 cM
Mapping Data

6 experiments

SNPs within 2kb

1239 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098231	protein coding gene	Chr19:37364830-37410311 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025080	protein coding gene	Chr19:36344775-36395959 (+)
A/J	MGP_AJ_G0025056	protein coding gene	Chr19:34592273-34638070 (+)
AKR/J	MGP_AKRJ_G0025024	protein coding gene	Chr19:35773214-35825486 (+)
BALB/cJ	MGP_BALBcJ_G0025054	protein coding gene	Chr19:34678318-34726148 (+)
C3H/HeJ	MGP_C3HHeJ_G0024813	protein coding gene	Chr19:35825543-35879785 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025495	protein coding gene	Chr19:37407339-37460753 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022913	protein coding gene	Chr19:33957698-34000564 (+)
CAST/EiJ	MGP_CASTEiJ_G0024280	protein coding gene	Chr19:35672874-35724256 (+)
CBA/J	MGP_CBAJ_G0024790	protein coding gene	Chr19:39138885-39196670 (+)
DBA/2J	MGP_DBA2J_G0024922	protein coding gene	Chr19:34446161-34491731 (+)
FVB/NJ	MGP_FVBNJ_G0024883	protein coding gene	Chr19:34256948-34302363 (+)
LP/J	MGP_LPJ_G0025008	protein coding gene	Chr19:36439134-36493460 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024914	protein coding gene	Chr19:38954986-39003508 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025553	protein coding gene	Chr19:35854597-35906157 (+)
PWK/PhJ	MGP_PWKPhJ_G0024032	protein coding gene	Chr19:34292149-34342002 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023832	protein coding gene	Chr19:34688844-34744518 (+)
WSB/EiJ	MGP_WSBEiJ_G0024347	protein coding gene	Chr19:35943532-35992424 (+)

Human Ortholog

KIF11, kinesin family member 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF11, kinesin family member 11
Synonyms

EG5, HKSP, KNSL1, MCLMR, TRIP5
Links

HGNC:6388

NCBI Gene ID: 3832

neXtProt AC: NX_P52732

UniProt: P52732
Chr Location

10q23.33; chr10:92574105-92655395 (+) GRCh38

MGI Vertebrate Homology

Kif11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF11
Gene Tree

Kif11

Diseases

1 with human KIF11 associations

				Human Disease	Mouse Models
				microcephaly with or without chorioretinopathy, lymphedema, or mental retardation IDs microcephaly with or without chorioretinopathy, lymphedema, or mental retardation DOID:0060349 MESH:C537711 OMIM:152950 ORDO:2526 UMLS_CUI:C1835265

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Endonuclease-mediated

5
Gene trapped

42
Targeted

5
Transgenic

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

122
cDNA Data

190
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF11

Xenbase kif11

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS29777.1

Ensembl

ENSMUSG00000012443 (Evidence)
NCBI Gene

16551

			Length	Strain/Species	Flank
genomic	ENSMUSG00000012443	Ensembl Gene Model \| MGI Sequence Detail	45457	C57BL/6J	± kb
transcript	ENSMUST00000012587	Ensembl \| MGI Sequence Detail	4819	Not Applicable
polypeptide	ENSMUSP00000012587	Ensembl \| MGI Sequence Detail	1052	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003045 kinesin-like protein KIF11

(term hierarchy)
InterPro Domains

IPR025901 Kinesin-associated microtubule-binding domain

IPR047149 Kinesin-like protein KIF11-like

IPR047241 Kinesin-like protein KIF11-like, kinesin motor domain

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q6P9P6 1 site, 1 O-linked glycan (1 site)

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All nucleic 198

Genomic 4

cDNA 192

Primer pair 2

Microarray probesets 5

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MGI:1306820

Summaries

All 69

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 16
Earliest

J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
Latest

J:334512 He S, et al., Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Nat Commun. 2023 Mar 27;14(1):1715

TSS for Kif11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156217	Chr19:37397173-37397189 (+)	32,330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24