Kif16b MGI Mouse Gene Detail - MGI:1098240

Symbol

Kif16b
Name

kinesin family member 16B
Synonyms

8430434E15Rik, mKIAA1590, N-3 kinesin

Feature Type

protein coding gene
IDs

MGI:1098240
NCBI Gene: 16558
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:142459394-142743451 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 70.67 cM, cytoband G3
Mapping Data

4 experiments

SNPs within 2kb

6941 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098240	protein coding gene	Chr2:142459394-142743535 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026573	protein coding gene	Chr2:146613379-146906608 (-)
A/J	MGP_AJ_G0026537	protein coding gene	Chr2:140662956-140947948 (-)
AKR/J	MGP_AKRJ_G0026511	protein coding gene	Chr2:144732616-145024083 (-)
BALB/cJ	MGP_BALBcJ_G0026549	protein coding gene	Chr2:141134018-141416383 (-)
C3H/HeJ	MGP_C3HHeJ_G0026292	protein coding gene	Chr2:145274947-145566239 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026994	protein coding gene	Chr2:151020261-151328883 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024371	protein coding gene	Chr2:134955870-135229533 (-)
CAST/EiJ	MGP_CASTEiJ_G0025753	protein coding gene	Chr2:145617380-145907633 (-)
CBA/J	MGP_CBAJ_G0026272	protein coding gene	Chr2:156561364-156867980 (-)
DBA/2J	MGP_DBA2J_G0026406	protein coding gene	Chr2:140018368-140292920 (-)
FVB/NJ	MGP_FVBNJ_G0026370	protein coding gene	Chr2:138573903-138852953 (-)
LP/J	MGP_LPJ_G0026510	protein coding gene	Chr2:146792289-147089751 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026390	protein coding gene	Chr2:160775094-161077407 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027049	protein coding gene	Chr2:144745753-145031718 (-)
PWK/PhJ	MGP_PWKPhJ_G0025489	protein coding gene	Chr2:139653093-139935118 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025290	protein coding gene	Chr2:143785245-144092459 (-)
WSB/EiJ	MGP_WSBEiJ_G0025826	protein coding gene	Chr2:145730292-146022259 (-)

Human Ortholog

KIF16B, kinesin family member 16B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF16B, kinesin family member 16B
Synonyms

C20orf23, KISC20ORF, SNX23
Links

HGNC:15869

NCBI Gene ID: 55614

neXtProt AC: NX_Q96L93

UniProt: Q96L93
Chr Location

20p12.1; chr20:16272104-16573448 (-) GRCh38

MGI Vertebrate Homology

Kif16b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF16B
Gene Tree

Kif16b

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

13
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Kif16b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

89 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Chimera embryos containing a knock-out allele and derived from tetraploid rescue exhibit lethal growth arrest at the blastocyst stage with abnormal development of the primitive endoderm, epiblast epithelium, and basement membrane.

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All GO Annotations

45
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF16B

Xenbase kif16b

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All Sequences

77
RefSeq

26
UniProt

4
CCDS

CCDS38251.1, CCDS89559.1

Ensembl

ENSMUSG00000038844 (Evidence)
NCBI Gene

16558

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038844	Ensembl Gene Model \| MGI Sequence Detail	284058	C57BL/6J	± kb
transcript	ENSMUST00000211861	Ensembl \| MGI Sequence Detail	4523	Not Applicable
polypeptide	ENSMUSP00000148731	Ensembl \| MGI Sequence Detail	1386	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009290 kinesin-like protein KIF16B

(term hierarchy)
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR001683 Phox homology

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR036871 PX domain superfamily

IPR008984 SMAD/FHA domain superfamily

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All nucleic 15

cDNA 15

Microarray probesets 6

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MGI:1918790, MGI:2139053, MGI:2139499, MGI:2139511, MGI:3034217

Summaries

All 48

Gene Ontology 9

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kif16b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26565	Chr2:142743426-142743496 (-)	-10 bp
Tssr26564	Chr2:142743354-142743394 (-)	77 bp
Tssr26563	Chr2:142721545-142721556 (-)	21,900 bp
Tssr26562	Chr2:142721505-142721524 (-)	21,936 bp
Tssr26561	Chr2:142680130-142680155 (-)	63,308 bp
Tssr26560	Chr2:142620387-142620391 (-)	123,062 bp
Tssr26559	Chr2:142608179-142608181 (-)	135,271 bp
Tssr26558	Chr2:142599968-142599976 (-)	143,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24