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Kif15 Gene Detail
Summary
  • Symbol
    Kif15
  • Name
    kinesin family member 15
  • Synonyms
    3110023M17Rik, 3930402I10Rik, HKLP2, Knsl7, N-10 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098258
    NCBI Gene: 209737
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122780146-122847798 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.31 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098258
 protein coding gene Chr9:122780111-122847798 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035468
 protein coding gene Chr9:125962541-126034479 (+)
A/J MGP_AJ_G0035449
 protein coding gene Chr9:121142117-121211347 (+)
AKR/J MGP_AKRJ_G0035382
 protein coding gene Chr9:124397759-124471660 (+)
BALB/cJ MGP_BALBcJ_G0035445
 protein coding gene Chr9:121069600-121142964 (+)
C3H/HeJ MGP_C3HHeJ_G0035152
 protein coding gene Chr9:124840007-124912132 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035968
 protein coding gene Chr9:129446923-129524815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032850
 protein coding gene Chr9:118280439-118349535 (+)
CAST/EiJ MGP_CASTEiJ_G0034457
 protein coding gene Chr9:124865534-124943721 (+)
CBA/J MGP_CBAJ_G0035120
 protein coding gene Chr9:134150014-134232325 (+)
DBA/2J MGP_DBA2J_G0035279
 protein coding gene Chr9:120586425-120665855 (+)
FVB/NJ MGP_FVBNJ_G0035226
 protein coding gene Chr9:119505574-119573684 (+)
LP/J MGP_LPJ_G0035358
 protein coding gene Chr9:126297283-126370985 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035267
 protein coding gene Chr9:135012862-135083603 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035987
 protein coding gene Chr9:124855786-124929571 (+)
PWK/PhJ MGP_PWKPhJ_G0034161
 protein coding gene Chr9:121050049-121121274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033998
 protein coding gene Chr9:124945074-125026978 (+)
WSB/EiJ MGP_WSBEiJ_G0034577
 protein coding gene Chr9:124701450-124773874 (+)



Homology
more
  • Human Ortholog
    KIF15, kinesin family member 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF15, kinesin family member 15
  • Synonyms
    BRDCS2, HKLP2, KLP2, KNSL7, NY-BR-62
  • Links
    NCBI Gene ID: 56992
    neXtProt AC: NX_Q9NS87
    UniProt: Q9NS87

  • Chr Location
    3p21.31; chr3:44761721-44873376 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit inhibited growth of transplanted tumor cells with increased CD8+ T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    133
  • cDNA Data
    78
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209737 NCBI Gene Model | MGI Sequence Detail 67653 C57BL/6J ±  kb
    transcript NM_010620 RefSeq | MGI Sequence Detail 4840 C57BL/6  
    polypeptide Q6P9L6 UniProt | EBI | MGI Sequence Detail 1387 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009289 kinesin-like protein KIF15
      (term hierarchy)
    • InterPro Domains
      IPR031794 Hyaluronan-mediated motility receptor, C-terminal
      IPR044986 Kinesin-like protein KIF15/KIN-12
      IPR001752 Kinesin motor domain
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q6P9L6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 81
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918015, MGI:1920396, MGI:5437723
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory