Kif1c MGI Mouse Gene Detail - MGI:1098260

Symbol

Kif1c
Name

kinesin family member 1C
Synonyms

B430105J22Rik, D11Bwg1349e, N-3 kinsin, Orch3

Feature Type

protein coding gene
IDs

MGI:1098260
NCBI Gene: 16562
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:70591374-70622790 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

10 experiments

SNPs within 2kb

285 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098260	protein coding gene	Chr11:70591170-70622796 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018614	protein coding gene	Chr11:71251294-71285692 (+)
A/J	MGP_AJ_G0018582	protein coding gene	Chr11:68557567-68588926 (+)
AKR/J	MGP_AKRJ_G0018551	protein coding gene	Chr11:70613427-70644532 (+)
BALB/cJ	MGP_BALBcJ_G0018554	protein coding gene	Chr11:68864713-68896328 (+)
C3H/HeJ	MGP_C3HHeJ_G0018367	protein coding gene	Chr11:70634843-70667424 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019005	protein coding gene	Chr11:73406795-73441849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016650	protein coding gene	Chr11:65461329-65493736 (+)
CAST/EiJ	MGP_CASTEiJ_G0017922	protein coding gene	Chr11:70906080-70939310 (+)
CBA/J	MGP_CBAJ_G0018339	protein coding gene	Chr11:76711499-76746044 (+)
DBA/2J	MGP_DBA2J_G0018449	protein coding gene	Chr11:68128188-68160121 (+)
FVB/NJ	MGP_FVBNJ_G0018439	protein coding gene	Chr11:67769930-67805481 (+)
LP/J	MGP_LPJ_G0018519	protein coding gene	Chr11:71828170-71861707 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018462	protein coding gene	Chr11:77261045-77298737 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019047	protein coding gene	Chr11:70872451-70903208 (+)
PWK/PhJ	MGP_PWKPhJ_G0017696	protein coding gene	Chr11:68775899-68951831 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017486	protein coding gene	Chr11:70689120-70722328 (+)
WSB/EiJ	MGP_WSBEiJ_G0017976	protein coding gene	Chr11:70533555-70569297 (+)

Human Ortholog

KIF1C, kinesin family member 1C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF1C, kinesin family member 1C
Synonyms

LTXS1, SATX2, SAX2, SPAX2, SPG58
Links

HGNC:6317

NCBI Gene ID: 10749

neXtProt AC: NX_O43896

UniProt: O43896
Chr Location

17p13.2; chr17:4997950-5028401 (+) GRCh38

MGI Vertebrate Homology

Kif1c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF1C
Gene Tree

Kif1c

Diseases

1 with human KIF1C associations

				Human Disease	Mouse Models
				spastic ataxia 2 IDs spastic ataxia 2 DOID:0050941 OMIM:611302

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 5 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
QTL

4
Targeted

4
Genomic Mutations

2 involving Kif1c
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele are viable, fertile and overtly normal and display normal motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

12
cDNA Data

107
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif1c

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All Sequences

71
RefSeq

21
UniProt

5
CCDS

CCDS24965.1

Ensembl

ENSMUSG00000020821 (Evidence)
NCBI Gene

16562

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020821	Ensembl Gene Model \| MGI Sequence Detail	31417	C57BL/6J	± kb
transcript	ENSMUST00000072187	Ensembl \| MGI Sequence Detail	5046	Not Applicable
polypeptide	ENSMUSP00000072048	Ensembl \| MGI Sequence Detail	1112	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009297 kinesin-like protein KIF1C

(term hierarchy)
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR032405 Kinesin-associated

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR008984 SMAD/FHA domain superfamily
GlyGen

O35071 1 site, 1 O-linked glycan (1 site)

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All nucleic 109

cDNA 107

Primer pair 2

Microarray probesets 6

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MGD-MRK-36568, MGI:106361, MGI:107988, MGI:1335095, MGI:2443544

Summaries

All 53

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Kif1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102787	Chr11:70591036-70591126 (+)	-293 bp
Tssr102788	Chr11:70591299-70591378 (+)	-35 bp
Tssr102789	Chr11:70591432-70591441 (+)	63 bp
Tssr102790	Chr11:70593111-70593122 (+)	1,743 bp
Tssr102791	Chr11:70593189-70593202 (+)	1,822 bp
Tssr102792	Chr11:70606637-70606644 (+)	15,267 bp
Tssr102793	Chr11:70609770-70609777 (+)	18,400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24