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Kif5c Gene Detail
Summary
  • Symbol
    Kif5c
  • Name
    kinesin family member 5C
  • Synonyms
    Khc, mKIAA0531
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098269
    NCBI Gene: 16574
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:49509310-49664790 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 28.68 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4687 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098269
 protein coding gene Chr2:49509298-49664790 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025723
 protein coding gene Chr2:48799623-48969787 (+)
A/J MGP_AJ_G0025699
 protein coding gene Chr2:46946716-47108721 (+)
AKR/J MGP_AKRJ_G0025669
 protein coding gene Chr2:48297564-48459063 (+)
BALB/cJ MGP_BALBcJ_G0025694
 protein coding gene Chr2:47068360-47226990 (+)
C3H/HeJ MGP_C3HHeJ_G0025455
 protein coding gene Chr2:48279349-48440601 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026140
 protein coding gene Chr2:50280236-50444977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023546
 protein coding gene Chr2:44991058-45149235 (+)
CAST/EiJ MGP_CASTEiJ_G0024920
 protein coding gene Chr2:48338204-48506274 (+)
CBA/J MGP_CBAJ_G0025435
 protein coding gene Chr2:52154523-52324418 (+)
DBA/2J MGP_DBA2J_G0025566
 protein coding gene Chr2:46574427-46730915 (+)
FVB/NJ MGP_FVBNJ_G0025528
 protein coding gene Chr2:46305378-46462061 (+)
LP/J MGP_LPJ_G0025654
 protein coding gene Chr2:48733780-48896767 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025559
 protein coding gene Chr2:53230138-53390058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026198
 protein coding gene Chr2:48197087-48358181 (+)
PWK/PhJ MGP_PWKPhJ_G0024661
 protein coding gene Chr2:46453932-46616559 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024467
 protein coding gene Chr2:48362706-48527756 (+)
WSB/EiJ MGP_WSBEiJ_G0024987
 protein coding gene Chr2:48457153-48619494 (+)



Homology
more
  • Human Ortholog
    KIF5C, kinesin family member 5C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF5C, kinesin family member 5C
  • Synonyms
    CDCBM2, KINN, NKHC, NKHC-2, NKHC2
  • Links
    NCBI Gene ID: 3800
    neXtProt AC: NX_O60282
    UniProt: O60282

  • Chr Location
    2q23.1-q23.2; chr2:148875227-149026759 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KIF5C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homezygous for disruptions in this gene are viable, fertile, and of normal size. The brain is normal but slightly reduced in size with decreased numbers of motor neurons an somewhat more sensory nerves than normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    89
  • cDNA Data
    258
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026764 Ensembl Gene Model | MGI Sequence Detail 155481 C57BL/6J ±  kb
    transcript ENSMUST00000028102 Ensembl | MGI Sequence Detail 6856 Not Applicable  
    polypeptide ENSMUSP00000028102 Ensembl | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 261
      cDNA 261

      Microarray probesets 7
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 12
      Gene Ontology 15
      Phenotypes 14
    • Earliest
      J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory