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Jag2 Gene Detail
Summary
  • Symbol
    Jag2
  • Name
    jagged 2
  • Synonyms
    D12Ggc2e, Serh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098270
    NCBI Gene: 16450
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112871439-112893396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.37 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098270
 protein coding gene Chr12:112871439-112893437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020164
 protein coding gene Chr12:115391391-115412297 (-)
A/J MGP_AJ_G0020120
 protein coding gene Chr12:110926298-110946557 (-)
AKR/J MGP_AKRJ_G0020095
 protein coding gene Chr12:114148185-114168461 (-)
BALB/cJ MGP_BALBcJ_G0020105
 protein coding gene Chr12:111387846-111408752 (-)
C3H/HeJ MGP_C3HHeJ_G0019907
 protein coding gene Chr12:114662939-114683214 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020550
 protein coding gene Chr12:118944031-118964936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018164
 protein coding gene Chr12:107361758-107383575 (-)
CAST/EiJ MGP_CASTEiJ_G0019447
 protein coding gene Chr12:109506171-109527195 (-)
CBA/J MGP_CBAJ_G0019874
 protein coding gene Chr12:123497884-123518159 (-)
DBA/2J MGP_DBA2J_G0019991
 protein coding gene Chr12:110426918-110447831 (-)
FVB/NJ MGP_FVBNJ_G0019976
 protein coding gene Chr12:109252050-109273087 (-)
LP/J MGP_LPJ_G0020065
 protein coding gene Chr12:115214974-115235878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020014
 protein coding gene Chr12:126593956-126614860 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020579
 protein coding gene Chr12:113665845-113686109 (-)
PWK/PhJ MGP_PWKPhJ_G0019209
 protein coding gene Chr12:105081835-105102862 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019013
 protein coding gene Chr12:107841516-107862681 (-)
WSB/EiJ MGP_WSBEiJ_G0019507
 protein coding gene Chr12:114576617-114596917 (-)



Homology
more
  • Human Ortholog
    JAG2, jagged canonical Notch ligand 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JAG2, jagged canonical Notch ligand 2
  • Synonyms
    HJ2, LGMDR27, SER2
  • Links
    NCBI Gene ID: 3714
    neXtProt AC: NX_Q9Y219
    UniProt: Q9Y219

  • Chr Location
    14q32.33; chr14:105140982-105168824 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human JAG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation die perinatally with craniofacial defects, fused digits, and increased numbers of sensory hair cells in the cochlea. Homozygotes for a spontaneous mutation exhibit fused digits and sometimes tail kinks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1203
  • Tissues
    266
  • cDNA Data
    60
  • Literature Summary
    146
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002799 Ensembl Gene Model | MGI Sequence Detail 21958 C57BL/6J ±  kb
    transcript ENSMUST00000075827 Ensembl | MGI Sequence Detail 5106 Not Applicable  
    polypeptide ENSMUSP00000075224 Ensembl | MGI Sequence Detail 1247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 8
      cDNA 64
      Primer pair 11
      Other 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14445, MGD-MRK-36557, MGD-MRK-39539, MGI:107977, MGI:109540, MGI:98321
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 146
      Gene Ontology 16
      Phenotypes 40
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:348290 Huang H, et al., Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool. Nat Commun. 2024 May 15;15(1):4124
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory