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Gse1 Gene Detail
Summary
  • Symbol
    Gse1
  • Name
    genetic suppressor element 1, coiled-coil protein
  • Synonyms
    mKIAA0182
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098275
    NCBI Gene: 382034
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120955233-121308122 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 69.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098275
 protein coding gene Chr8:120955195-121308129 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034200
 protein coding gene Chr8:123628725-124013769 (+)
A/J MGP_AJ_G0034180
 protein coding gene Chr8:118506275-118863665 (+)
AKR/J MGP_AKRJ_G0034107
 protein coding gene Chr8:121942926-122313526 (+)
BALB/cJ MGP_BALBcJ_G0034174
 protein coding gene Chr8:118717603-119079052 (+)
C3H/HeJ MGP_C3HHeJ_G0033885
 protein coding gene Chr8:122676886-123054986 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034694
 protein coding gene Chr8:127741785-128136091 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031636
 protein coding gene Chr8:111385625-111739967 (+)
CAST/EiJ MGP_CASTEiJ_G0033212
 protein coding gene Chr8:122659954-123051785 (+)
CBA/J MGP_CBAJ_G0033858
 protein coding gene Chr8:132414059-132822775 (+)
DBA/2J MGP_DBA2J_G0034014
 protein coding gene Chr8:117725841-118082736 (+)
FVB/NJ MGP_FVBNJ_G0033957
 protein coding gene Chr8:116785345-117155409 (+)
LP/J MGP_LPJ_G0034103
 protein coding gene Chr8:123760246-124134396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034004
 protein coding gene Chr8:134812483-135189238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034712
 protein coding gene Chr8:122110061-122488618 (+)
PWK/PhJ MGP_PWKPhJ_G0032914
 protein coding gene Chr8:117498235-117860438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032754
 protein coding gene Chr8:120804637-121190967 (+)
WSB/EiJ MGP_WSBEiJ_G0033328
 protein coding gene Chr8:122846562-123226781 (+)



Homology
more
  • Human Ortholog
    GSE1, Gse1 coiled-coil protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSE1, Gse1 coiled-coil protein
  • Synonyms
    CRHSP24, KIAA0182
  • Links
    NCBI Gene ID: 23199
    neXtProt AC: NX_Q14687
    UniProt: Q14687

  • Chr Location
    16q24.1; chr16:85169512-85676204 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GSE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382034 NCBI Gene Model | MGI Sequence Detail 352890 C57BL/6J ±  kb
    transcript NM_198671 RefSeq | MGI Sequence Detail 6716 C57BL/6  
    polypeptide Q3U3C9 UniProt | EBI | MGI Sequence Detail 1213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008283 genetic suppressor element 1
      (term hierarchy)
    • InterPro Domains
      IPR042337 Genetic suppressor element 1
      IPR022207 Genetic suppressor element-like
    • GlyGen
      Q3U3C9 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 6
      Phenotypes 8
    • Earliest
      J:43245 Gudkov AV, et al., Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3744-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory