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Cpt1b Gene Detail
Summary
  • Symbol
    Cpt1b
  • Name
    carnitine palmitoyltransferase 1b, muscle
  • Synonyms
    Cpt1, M-CPT I, M-CPTI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098297
    NCBI Gene: 12895
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89300608-89310065 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098297
 protein coding gene Chr15:89300608-89310066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022235
 protein coding gene Chr15:90611079-90621568 (-)
A/J MGP_AJ_G0022194
 protein coding gene Chr15:87146135-87156374 (-)
AKR/J MGP_AKRJ_G0022169
 protein coding gene Chr15:89728827-89738217 (-)
BALB/cJ MGP_BALBcJ_G0022200
 protein coding gene Chr15:87250681-87261377 (-)
C3H/HeJ MGP_C3HHeJ_G0021970
 protein coding gene Chr15:89722345-89736968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022645
 protein coding gene Chr15:93906305-93922305 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020170
 protein coding gene Chr15:83371388-83380631 (-)
CAST/EiJ MGP_CASTEiJ_G0021492
 protein coding gene Chr15:90502659-90516354 (-)
CBA/J MGP_CBAJ_G0021937
 protein coding gene Chr15:97089628-97102185 (-)
DBA/2J MGP_DBA2J_G0022064
 protein coding gene Chr15:86597135-86607162 (-)
FVB/NJ MGP_FVBNJ_G0022043
 protein coding gene Chr15:85664773-85674282 (-)
LP/J MGP_LPJ_G0022135
 protein coding gene Chr15:90769158-90779237 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022063
 protein coding gene Chr15:101486912-101499823 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022660
 protein coding gene Chr15:89763549-89775020 (-)
PWK/PhJ MGP_PWKPhJ_G0021233
 protein coding gene Chr15:86660190-86670428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021067
 protein coding gene Chr15:89510580-89524006 (-)
WSB/EiJ MGP_WSBEiJ_G0021541
 protein coding gene Chr15:90251866-90265197 (-)



Homology
more
  • Human Ortholog
    CPT1B, carnitine palmitoyltransferase 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPT1B, carnitine palmitoyltransferase 1B
  • Synonyms
    CPT1-M, CPT1M, CPTI, CPTI-M, MCCPT1, M-CPT1, MCPT1
  • Links
    NCBI Gene ID: 1375
    neXtProt AC: NX_Q92523
    UniProt: Q92523

  • Chr Location
    22q13.33; chr22:50568861-50578612 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die in utero prior to E9.5. Heterozygous mutant mice exhibit susceptibility to fatal hypothermia following cold exposure, with females more severely affected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    116
  • cDNA Data
    32
  • Literature Summary
    26
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12895 NCBI Gene Model | MGI Sequence Detail 9458 C57BL/6J ±  kb
transcript NM_009948 RefSeq | MGI Sequence Detail 2894 ZRU/MplStud  
polypeptide Q924X2 UniProt | EBI | MGI Sequence Detail 772 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005836 carnitine O-palmitoyltransferase 1, muscle isoform
    (term hierarchy)
  • EC
    2.3.1.21
  • InterPro Domains
    IPR000542 Acyltransferase ChoActase/COT/CPT
    IPR032476 Carnitine O-palmitoyltransferase, N-terminal
    IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
    IPR039551 Choline/carnitine acyltransferase domain
    IPR042231 Choline/Carnitine o-acyltransferase, domain 2
  • GlyGen
    Q924X2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 43
    Genomic 3
    cDNA 33
    Primer pair 7

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2118
References
more
  • Summaries
    All 95
    Developmental Gene Expression 26
    Diseases 1
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory