Alg3 MGI Mouse Gene Detail - MGI:1098592 - ALG3 alpha-1,3- mannosyltransferase

Symbol

Alg3
Name

ALG3 alpha-1,3- mannosyltransferase
Synonyms

D16Ertd36e

Feature Type

protein coding gene
IDs

MGI:1098592
NCBI Gene: 208624
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:20424208-20429515 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.48 cM
Mapping Data

3 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098592	protein coding gene	Chr16:20424124-20430485 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022647	protein coding gene	Chr16:17942874-17948191 (-)
A/J	MGP_AJ_G0022609	protein coding gene	Chr16:17079932-17085246 (-)
AKR/J	MGP_AKRJ_G0022584	protein coding gene	Chr16:17726588-17731905 (-)
BALB/cJ	MGP_BALBcJ_G0022613	protein coding gene	Chr16:17237599-17242916 (-)
C3H/HeJ	MGP_C3HHeJ_G0022378	protein coding gene	Chr16:17892828-17898145 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023064	protein coding gene	Chr16:18290183-18295500 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020581	protein coding gene	Chr16:17765534-17770857 (-)
CAST/EiJ	MGP_CASTEiJ_G0021908	protein coding gene	Chr16:17866942-17872251 (-)
CBA/J	MGP_CBAJ_G0022350	protein coding gene	Chr16:19043183-19048500 (-)
DBA/2J	MGP_DBA2J_G0022482	protein coding gene	Chr16:17006222-17011539 (-)
FVB/NJ	MGP_FVBNJ_G0022457	protein coding gene	Chr16:17041723-17047040 (-)
LP/J	MGP_LPJ_G0022549	protein coding gene	Chr16:17674696-17680013 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022477	protein coding gene	Chr16:18723403-18728720 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023075	protein coding gene	Chr16:17691864-17697181 (-)
PWK/PhJ	MGP_PWKPhJ_G0021649	protein coding gene	Chr16:17268775-17274569 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021478	protein coding gene	Chr16:17489450-17495533 (-)
WSB/EiJ	MGP_WSBEiJ_G0021952	protein coding gene	Chr16:17682585-17691121 (-)

Human Ortholog

ALG3, ALG3 alpha-1,3- mannosyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALG3, ALG3 alpha-1,3- mannosyltransferase
Synonyms

CDG1D, CDGS4, CDGS6, D16Ertd36e, not, Not56, NOT56L
Links

HGNC:23056

NCBI Gene ID: 10195

neXtProt AC: NX_Q92685

UniProt: Q92685
Chr Location

3q27.1; chr3:184242301-184249548 (-) GRCh38

MGI Vertebrate Homology

Alg3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALG3
Gene Tree

Alg3

Diseases

1 with human ALG3 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation Id IDs congenital disorder of glycosylation Id DOID:0080556 OMIM:601110 ORDO:79321

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

4
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

103
cDNA Data

42
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alg3

ZFIN alg3

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All Sequences

109
RefSeq

16
UniProt

13
CCDS

CCDS37289.1, CCDS88898.1

Ensembl

ENSMUSG00000033809 (Evidence)
NCBI Gene

208624

			Length	Strain/Species	Flank
genomic	208624	NCBI Gene Model \| MGI Sequence Detail	5308	C57BL/6J	± kb
transcript	NM_145939	RefSeq \| MGI Sequence Detail	1437	ZRU/MplStud
polypeptide	Q8K2A8	UniProt \| EBI \| MGI Sequence Detail	438	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000003944 dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase

(term hierarchy)
EC

2.4.1.258
InterPro Domains

IPR007873 Glycosyltransferase, ALG3

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 7
Earliest

J:50320 Pappano WN, et al., Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Genomics. 1998 Sep 1;52(2):236-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Alg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140390	Chr16:20429491-20429507 (-)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24