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Psmc3ip Gene Detail
Summary
  • Symbol
    Psmc3ip
  • Name
    proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
  • Synonyms
    HOP2, Tbpip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098610
    NCBI Gene: 19183
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100982649-100986262 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.19 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098610
 protein coding gene Chr11:100981238-100986262 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019180
 protein coding gene Chr11:103902645-103906258 (-)
A/J MGP_AJ_G0019148
 protein coding gene Chr11:99549101-99552714 (-)
AKR/J MGP_AKRJ_G0019117
 protein coding gene Chr11:102646134-102649747 (-)
BALB/cJ MGP_BALBcJ_G0019122
 protein coding gene Chr11:100043609-100047222 (-)
C3H/HeJ MGP_C3HHeJ_G0018931
 protein coding gene Chr11:102816056-102819669 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019571
 protein coding gene Chr11:107117764-107121377 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017197
 protein coding gene Chr11:96967235-96970822 (-)
CAST/EiJ MGP_CASTEiJ_G0018485
 protein coding gene Chr11:103804376-103807982 (-)
CBA/J MGP_CBAJ_G0018900
 protein coding gene Chr11:111581601-111585214 (-)
DBA/2J MGP_DBA2J_G0019012
 protein coding gene Chr11:99084114-99087727 (-)
FVB/NJ MGP_FVBNJ_G0019002
 protein coding gene Chr11:98627459-98631072 (-)
LP/J MGP_LPJ_G0019081
 protein coding gene Chr11:104452504-104456117 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019033
 protein coding gene Chr11:111150141-111153754 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019609
 protein coding gene Chr11:102965676-102969289 (-)
PWK/PhJ MGP_PWKPhJ_G0018248
 protein coding gene Chr11:100134885-100138497 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018040
 protein coding gene Chr11:102700793-102704384 (-)
WSB/EiJ MGP_WSBEiJ_G0018534
 protein coding gene Chr11:102964044-102967657 (-)



Homology
more
  • Human Ortholog
    PSMC3IP, PSMC3 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMC3IP, PSMC3 interacting protein
  • Synonyms
    GT198, HOP2, HUMGT198A, ODG3, TBPIP
  • Links
    NCBI Gene ID: 29893
    neXtProt AC: NX_Q9P2W1
    UniProt: Q9P2W1

  • Chr Location
    17q21.2; chr17:42572310-42577831 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMC3IP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are mice were viable, showed no overt anatomical defects in somatic tissues, but are infertile in both sex due to absence of gametes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    11
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019303 Ensembl Gene Model | MGI Sequence Detail 3614 C57BL/6J ±  kb
    transcript ENSMUST00000019447 Ensembl | MGI Sequence Detail 1291 Not Applicable  
    polypeptide ENSMUSP00000019447 Ensembl | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013381 homologous-pairing protein 2
      (term hierarchy)
    • PDB
      2MH2
    • InterPro Domains
      IPR010776 Homologous-pairing protein 2, winged helix domain
      IPR040661 Leucine zipper with capping helix domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144650
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:43564 Tanaka T, et al., Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81
    • Latest
      J:333243 de la Fuente R, et al., Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis. Cells. 2021 Sep 3;10(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory