Mfhas1 MGI Mouse Gene Detail - MGI:1098644 - malignant fibrous histiocytoma amplified sequence 1

Symbol

Mfhas1
Name

malignant fibrous histiocytoma amplified sequence 1
Synonyms

2310066G09Rik, D8Ertd91e

Feature Type

protein coding gene
IDs

MGI:1098644
NCBI Gene: 52065
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:36054952-36146603 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 21.16 cM
Mapping Data

3 experiments

SNPs within 2kb

3237 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098644	protein coding gene	Chr8:36054922-36146603 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033539	protein coding gene	Chr8:34207169-34302009 (+)
A/J	MGP_AJ_G0033519	protein coding gene	Chr8:32831944-32930629 (+)
AKR/J	MGP_AKRJ_G0033443	protein coding gene	Chr8:33876920-33967154 (+)
BALB/cJ	MGP_BALBcJ_G0033515	protein coding gene	Chr8:32969480-33059994 (+)
C3H/HeJ	MGP_C3HHeJ_G0033227	protein coding gene	Chr8:34216992-34309103 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034031	protein coding gene	Chr8:35481619-35584054 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030980	protein coding gene	Chr8:29798402-29890279 (+)
CAST/EiJ	MGP_CASTEiJ_G0032554	protein coding gene	Chr8:33679222-33775929 (+)
CBA/J	MGP_CBAJ_G0033205	protein coding gene	Chr8:36866842-36979602 (+)
DBA/2J	MGP_DBA2J_G0033358	protein coding gene	Chr8:32782275-32874090 (+)
FVB/NJ	MGP_FVBNJ_G0033303	protein coding gene	Chr8:32444570-32534932 (+)
LP/J	MGP_LPJ_G0033448	protein coding gene	Chr8:34156074-34252493 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033345	protein coding gene	Chr8:36316974-36417672 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034050	protein coding gene	Chr8:33989403-34084770 (+)
PWK/PhJ	MGP_PWKPhJ_G0032265	protein coding gene	Chr8:32330181-32426647 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032096	protein coding gene	Chr8:33243389-33365649 (+)
WSB/EiJ	MGP_WSBEiJ_G0032670	protein coding gene	Chr8:34169165-34268261 (+)

Human Ortholog

MFHAS1, multifunctional ROCO family signaling regulator 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MFHAS1, multifunctional ROCO family signaling regulator 1
Synonyms

LRRC65, MASL1, ROCO4
Links

HGNC:16982

NCBI Gene ID: 9258

neXtProt AC: NX_Q9Y4C4

UniProt: Q9Y4C4
Chr Location

8p23.1; chr8:8783354-8893630 (-) GRCh38

MGI Vertebrate Homology

Mfhas1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MFHAS1
Gene Tree

Mfhas1

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Phenotype Summary

1 phenotype reference

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

44
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

10
cDNA Data

59
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mfhas1

ZFIN mfhas1

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All Sequences

45
RefSeq

6
UniProt

2
CCDS

CCDS40319.1

Ensembl

ENSMUSG00000070056 (Evidence)
NCBI Gene

52065

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070056	Ensembl Gene Model \| MGI Sequence Detail	91652	C57BL/6J	± kb
transcript	ENSMUST00000037666	Ensembl \| MGI Sequence Detail	6408	Not Applicable
polypeptide	ENSMUSP00000044135	Ensembl \| MGI Sequence Detail	1048	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010368 malignant fibrous histiocytoma-amplified sequence 1

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR050715 Leucine-rich repeat and signaling effector domain-containing protein

IPR050216 Leucine-rich repeat domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR020859 Roc domain

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All nucleic 60

cDNA 59

Primer pair 1

Microarray probesets 3

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MGI:1919190

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 1
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:262346 Zhong J, et al., MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB Signaling Pathway Following Negative Regulation. PLoS One. 2015;10(11):e0143662

TSS for Mfhas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76899	Chr8:36054934-36054979 (+)	5 bp
Tssr76900	Chr8:36054982-36055004 (+)	41 bp
Tssr76901	Chr8:36069309-36069313 (+)	14,359 bp
Tssr76902	Chr8:36070068-36070074 (+)	15,119 bp
Tssr76903	Chr8:36087948-36087952 (+)	32,998 bp
Tssr76904	Chr8:36139513-36139520 (+)	84,565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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