Odf2 MGI Mouse Gene Detail - MGI:1098824 - outer dense fiber of sperm tails 2

Symbol

Odf2
Name

outer dense fiber of sperm tails 2
Synonyms

cenexin, MMTEST29

Feature Type

protein coding gene
IDs

MGI:1098824
NCBI Gene: 18286
Alliance

gene page
Transcription Start Sites

24 TSS

Sequence Map

Chr2:29779233-29821758 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 20.79 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

914 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098824	protein coding gene	Chr2:29779026-29821758 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025547	protein coding gene	Chr2:28060068-28103929 (+)
A/J	MGP_AJ_G0025525	protein coding gene	Chr2:26961080-27005700 (+)
AKR/J	MGP_AKRJ_G0025494	protein coding gene	Chr2:27877491-27926720 (+)
BALB/cJ	MGP_BALBcJ_G0025520	protein coding gene	Chr2:27094268-27137202 (+)
C3H/HeJ	MGP_C3HHeJ_G0025282	protein coding gene	Chr2:27802981-27845219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025965	protein coding gene	Chr2:28973363-29016904 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023374	protein coding gene	Chr2:25751821-25795939 (+)
CAST/EiJ	MGP_CASTEiJ_G0024745	protein coding gene	Chr2:27694369-27737993 (+)
CBA/J	MGP_CBAJ_G0025259	protein coding gene	Chr2:29982921-30025129 (+)
DBA/2J	MGP_DBA2J_G0025392	protein coding gene	Chr2:26758376-26801744 (+)
FVB/NJ	MGP_FVBNJ_G0025355	protein coding gene	Chr2:26562017-26607025 (+)
LP/J	MGP_LPJ_G0025478	protein coding gene	Chr2:27984327-28030153 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025385	protein coding gene	Chr2:29902110-29947927 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026024	protein coding gene	Chr2:27797239-27842138 (+)
PWK/PhJ	MGP_PWKPhJ_G0024491	protein coding gene	Chr2:26587257-26629538 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024291	protein coding gene	Chr2:27872794-27915367 (+)
WSB/EiJ	MGP_WSBEiJ_G0024813	protein coding gene	Chr2:27914376-27958999 (+)

Human Ortholog

ODF2, outer dense fiber of sperm tails 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ODF2, outer dense fiber of sperm tails 2
Synonyms

CT134, ODF2/1, ODF2/2, ODF84
Links

HGNC:8114

NCBI Gene ID: 4957

neXtProt AC: NX_Q5BJF6

UniProt: Q5BJF6
Chr Location

9q34.11; chr9:128455185-128501292 (+) GRCh38

MGI Vertebrate Homology

Odf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ODF2
Gene Tree

Odf2

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Phenotype Summary

31 phenotypes from 4 alleles in 4 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

1
Gene trapped

19
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit embryonic lethality before implantation and transmission ratio distortion while all heterozygous males display normal development and fertility. Males heterozygous for other alleles are either infertile or show reduced fertility.

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All GO Annotations

32
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

28
cDNA Data

13
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase odf2

ZFIN odf2b

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All Sequences

166
RefSeq

75
UniProt

10
CCDS

CCDS15861.1, CCDS50554.1, CCDS50555.1, CCDS50556.1, CCDS50557.1, CCDS89461.1, CCDS89462.1

Ensembl

ENSMUSG00000026790 (Evidence)
NCBI Gene

18286

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026790	Ensembl Gene Model \| MGI Sequence Detail	42526	C57BL/6J	± kb
transcript	ENSMUST00000113765	Ensembl \| MGI Sequence Detail	3188	Not Applicable
polypeptide	ENSMUSP00000109394	Ensembl \| MGI Sequence Detail	830	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011598 outer dense fiber protein 2

(term hierarchy)
InterPro Domains

IPR026099 Outer dense fibre protein 2-related

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All nucleic 19

cDNA 15

Primer pair 4

Microarray probesets 8

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MGI:2139073

Summaries

All 82

Developmental Gene Expression 17

Gene Ontology 25

Phenotypes 16
Earliest

J:42726 Nakayama H, et al., Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev Genet. 1997;21(1):21-30
Latest

J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1

TSS for Odf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17034	Chr2:29779211-29779218 (+)	-18 bp
Tssr17035	Chr2:29779229-29779255 (+)	9 bp
Tssr452	Chr2:29779721-29779728 (+)	492 bp
Tssr17036	Chr2:29779754-29779765 (+)	527 bp
Tssr17037	Chr2:29779814-29779848 (+)	598 bp
Tssr453	Chr2:29780000-29780005 (+)	770 bp
Tssr454	Chr2:29780017-29780028 (+)	790 bp
Tssr455	Chr2:29780050-29780057 (+)	821 bp
Tssr17038	Chr2:29780078-29780093 (+)	853 bp
Tssr17039	Chr2:29780108-29780119 (+)	881 bp
Tssr456	Chr2:29780122-29780126 (+)	891 bp
Tssr17040	Chr2:29780458-29780523 (+)	1,258 bp
Tssr17041	Chr2:29780532-29780543 (+)	1,305 bp
Tssr17042	Chr2:29780546-29780557 (+)	1,319 bp
Tssr17043	Chr2:29780567-29780568 (+)	1,335 bp
Tssr17044	Chr2:29780710-29780722 (+)	1,483 bp
Tssr17045	Chr2:29780873-29780880 (+)	1,644 bp
Tssr17046	Chr2:29781997-29782019 (+)	2,775 bp
Tssr17047	Chr2:29783066-29783085 (+)	3,843 bp
Tssr457	Chr2:29793320-29793331 (+)	14,093 bp
Tssr17048	Chr2:29793554-29793569 (+)	14,329 bp
Tssr17049	Chr2:29793580-29793608 (+)	14,361 bp
Tssr17050	Chr2:29804457-29804461 (+)	25,226 bp
Tssr17051	Chr2:29810780-29810809 (+)	31,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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