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Odf2 Gene Detail
Summary
  • Symbol
    Odf2
  • Name
    outer dense fiber of sperm tails 2
  • Synonyms
    cenexin, MMTEST29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098824
    NCBI Gene: 18286
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:29779233-29821758 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 20.79 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    914 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098824
 protein coding gene Chr2:29779026-29821758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025547
 protein coding gene Chr2:28060068-28103929 (+)
A/J MGP_AJ_G0025525
 protein coding gene Chr2:26961080-27005700 (+)
AKR/J MGP_AKRJ_G0025494
 protein coding gene Chr2:27877491-27926720 (+)
BALB/cJ MGP_BALBcJ_G0025520
 protein coding gene Chr2:27094268-27137202 (+)
C3H/HeJ MGP_C3HHeJ_G0025282
 protein coding gene Chr2:27802981-27845219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025965
 protein coding gene Chr2:28973363-29016904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023374
 protein coding gene Chr2:25751821-25795939 (+)
CAST/EiJ MGP_CASTEiJ_G0024745
 protein coding gene Chr2:27694369-27737993 (+)
CBA/J MGP_CBAJ_G0025259
 protein coding gene Chr2:29982921-30025129 (+)
DBA/2J MGP_DBA2J_G0025392
 protein coding gene Chr2:26758376-26801744 (+)
FVB/NJ MGP_FVBNJ_G0025355
 protein coding gene Chr2:26562017-26607025 (+)
LP/J MGP_LPJ_G0025478
 protein coding gene Chr2:27984327-28030153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025385
 protein coding gene Chr2:29902110-29947927 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026024
 protein coding gene Chr2:27797239-27842138 (+)
PWK/PhJ MGP_PWKPhJ_G0024491
 protein coding gene Chr2:26587257-26629538 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024291
 protein coding gene Chr2:27872794-27915367 (+)
WSB/EiJ MGP_WSBEiJ_G0024813
 protein coding gene Chr2:27914376-27958999 (+)



Homology
more
  • Human Ortholog
    ODF2, outer dense fiber of sperm tails 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ODF2, outer dense fiber of sperm tails 2
  • Synonyms
    CT134, ODF2/1, ODF2/2, ODF84
  • Links
    NCBI Gene ID: 4957
    neXtProt AC: NX_Q5BJF6
    UniProt: Q5BJF6

  • Chr Location
    9q34.11; chr9:128455185-128501292 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality before implantation and transmission ratio distortion while all heterozygous males display normal development and fertility. Males heterozygous for other alleles are either infertile or show reduced fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026790 Ensembl Gene Model | MGI Sequence Detail 42526 C57BL/6J ±  kb
    transcript ENSMUST00000113765 Ensembl | MGI Sequence Detail 3188 Not Applicable  
    polypeptide ENSMUSP00000109394 Ensembl | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139073
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 17
      Gene Ontology 25
      Phenotypes 16
    • Earliest
      J:42726 Nakayama H, et al., Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev Genet. 1997;21(1):21-30
    • Latest
      J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory