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Rad51b Gene Detail
Summary
  • Symbol
    Rad51b
  • Name
    RAD51 paralog B
  • Synonyms
    mREC2, R51H2, Rad51b, Rad51l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099436
    NCBI Gene: 19363
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79344056-79861464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12934 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099436
 protein coding gene Chr12:79344032-79895034 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019884
 protein coding gene Chr12:79586991-79813935 (+)
A/J MGP_AJ_G0019842
 protein coding gene Chr12:76728748-76940219 (+)
AKR/J MGP_AKRJ_G0019817
 protein coding gene Chr12:78804738-79026298 (+)
BALB/cJ MGP_BALBcJ_G0019821
 protein coding gene Chr12:76977216-77191988 (+)
C3H/HeJ MGP_C3HHeJ_G0019627
 protein coding gene Chr12:79281752-79500671 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020273
 protein coding gene Chr12:81941178-82176894 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017892
 protein coding gene Chr12:73747216-73958287 (+)
CAST/EiJ MGP_CASTEiJ_G0019177
 protein coding gene Chr12:74119697-74344661 (+)
CBA/J MGP_CBAJ_G0019598
 protein coding gene Chr12:85121465-85378796 (+)
DBA/2J MGP_DBA2J_G0019713
 protein coding gene Chr12:76346715-76561369 (+)
FVB/NJ MGP_FVBNJ_G0019699
 protein coding gene Chr12:75161825-75376427 (+)
LP/J MGP_LPJ_G0019785
 protein coding gene Chr12:79528222-79755737 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019738
 protein coding gene Chr12:88203524-88435431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020308
 protein coding gene Chr12:78320567-78542821 (+)
PWK/PhJ MGP_PWKPhJ_G0018943
 protein coding gene Chr12:70712308-70929772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018737
 protein coding gene Chr12:72821869-73034544 (+)
WSB/EiJ MGP_WSBEiJ_G0019230
 protein coding gene Chr12:78943215-79171984 (+)



Homology
more
  • Human Ortholog
    RAD51B, RAD51 paralog B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD51B, RAD51 paralog B
  • Synonyms
    R51H2, RAD51L1, REC2
  • Links
    NCBI Gene ID: 5890
    neXtProt AC: NX_O15315
    UniProt: O15315

  • Chr Location
    14q24.1; chr14:67819779-68730218 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    20
  • Targeted
    3
  • Genomic Mutations
    1 involving Rad51b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    25 strains or lines available
Embryos homozygous for a knock-out allele are severely growth retarded and exhibit complete early embryonic lethality; interestingly, mutant embryos survive and develop further in a Trp53-null background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    9
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059060 Ensembl Gene Model | MGI Sequence Detail 517409 C57BL/6J ±  kb
transcript ENSMUST00000171210 Ensembl | MGI Sequence Detail 1858 Not Applicable  
polypeptide ENSMUSP00000128357 Ensembl | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013676 DNA repair protein RAD51 homolog 2
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR030548 DNA repair protein RAD51 homologue 2
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 20
    Genomic 2
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144860
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:41747 Rice MC, et al., Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
  • Latest
    J:336101 Dickinson K, et al., WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis. Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F245-F255
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory