Stk10 MGI Mouse Gene Detail - MGI:1099439 - serine/threonine kinase 10

Symbol

Stk10
Name

serine/threonine kinase 10
Synonyms

Gek1, Lok

Feature Type

protein coding gene
IDs

MGI:1099439
NCBI Gene: 20868
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:32483305-32574587 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 18.97 cM, cytoband A4
Mapping Data

4 experiments

SNPs within 2kb

2642 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099439	protein coding gene	Chr11:32483266-32574595 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018137	protein coding gene	Chr11:30773492-30868015 (+)
A/J	MGP_AJ_G0018110	protein coding gene	Chr11:29594105-29686990 (+)
AKR/J	MGP_AKRJ_G0018074	protein coding gene	Chr11:30531718-30623937 (+)
BALB/cJ	MGP_BALBcJ_G0018079	protein coding gene	Chr11:29786349-29878250 (+)
C3H/HeJ	MGP_C3HHeJ_G0017892	protein coding gene	Chr11:30471798-30571313 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018533	protein coding gene	Chr11:31775283-31872832 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016188	protein coding gene	Chr11:28118636-28211730 (+)
CAST/EiJ	MGP_CASTEiJ_G0017456	protein coding gene	Chr11:30515577-30611632 (+)
CBA/J	MGP_CBAJ_G0017865	protein coding gene	Chr11:33285854-33385122 (+)
DBA/2J	MGP_DBA2J_G0017975	protein coding gene	Chr11:29388086-29479599 (+)
FVB/NJ	MGP_FVBNJ_G0017969	protein coding gene	Chr11:29212976-29304149 (+)
LP/J	MGP_LPJ_G0018047	protein coding gene	Chr11:31032263-31125905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017993	protein coding gene	Chr11:34259029-34358796 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018572	protein coding gene	Chr11:30662908-30762738 (+)
PWK/PhJ	MGP_PWKPhJ_G0017237	protein coding gene	Chr11:29544637-29641815 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017029	protein coding gene	Chr11:30363030-30463833 (+)
WSB/EiJ	MGP_WSBEiJ_G0017505	protein coding gene	Chr11:30297967-30395698 (+)

Human Ortholog

STK10, serine/threonine kinase 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK10, serine/threonine kinase 10
Synonyms

LOK, PRO2729
Links

HGNC:11388

NCBI Gene ID: 6793

neXtProt AC: NX_O94804

UniProt: O94804
Chr Location

5q35.1; chr5:172042079-172188224 (-) GRCh38

MGI Vertebrate Homology

Stk10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STK10
Gene Tree

Stk10

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Stk10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

45
cDNA Data

54
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA STK10

Xenbase stk10

ZFIN stk10

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All Sequences

44
RefSeq

6
UniProt

4
CCDS

CCDS24529.1

Ensembl

ENSMUSG00000020272 (Evidence)
NCBI Gene

20868

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020272	Ensembl Gene Model \| MGI Sequence Detail	91283	C57BL/6J	± kb
transcript	ENSMUST00000102821	Ensembl \| MGI Sequence Detail	5026	Not Applicable
polypeptide	ENSMUSP00000099885	Ensembl \| MGI Sequence Detail	966	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015739 serine/threonine-protein kinase 10

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR022165 Polo kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR042743 Serine/threonine-protein kinase 10, catalytic domain

IPR008271 Serine/threonine-protein kinase, active site

IPR051585 STE20 Subfamily Serine/Threonine Kinases
GlyGen

O55098 1 site, 1 O-linked glycan (1 site)

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All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 3

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MGD-MRK-37543, MGI:108499

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Stk10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100857	Chr11:32482845-32482870 (+)	-447 bp
Tssr100858	Chr11:32483290-32483301 (+)	-9 bp
Tssr100859	Chr11:32483309-32483335 (+)	17 bp
Tssr100860	Chr11:32485982-32485997 (+)	2,685 bp
Tssr100861	Chr11:32504285-32504334 (+)	21,005 bp
Tssr100862	Chr11:32504906-32504915 (+)	21,606 bp
Tssr100863	Chr11:32504966-32504978 (+)	21,667 bp
Tssr100864	Chr11:32513065-32513074 (+)	29,765 bp
Tssr100865	Chr11:32561046-32561060 (+)	77,748 bp
Tssr100866	Chr11:32561064-32561083 (+)	77,769 bp
Tssr100867	Chr11:32564748-32564783 (+)	81,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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