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Golgb1 Gene Detail
Summary
  • Symbol
    Golgb1
  • Name
    golgin B1
  • Synonyms
    6330407A06Rik, C130074L01Rik, F730017E11Rik, Giantin, Gm6840
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099447
    NCBI Gene: 224139
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36695502-36753447 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.19 cM, cytoband B4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1480 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099447
 protein coding gene Chr16:36695455-36753447 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022795
 protein coding gene Chr16:35296640-35355808 (+)
A/J MGP_AJ_G0022760
 protein coding gene Chr16:33555897-33613890 (+)
AKR/J MGP_AKRJ_G0022732
 protein coding gene Chr16:34839502-34897433 (+)
BALB/cJ MGP_BALBcJ_G0022761
 protein coding gene Chr16:33659486-33717466 (+)
C3H/HeJ MGP_C3HHeJ_G0022525
 protein coding gene Chr16:34956441-35014396 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023208
 protein coding gene Chr16:36139519-36197702 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020722
 protein coding gene Chr16:33921270-33977994 (+)
CAST/EiJ MGP_CASTEiJ_G0022051
 protein coding gene Chr16:35077107-35135989 (+)
CBA/J MGP_CBAJ_G0022496
 protein coding gene Chr16:37718863-37776850 (+)
DBA/2J MGP_DBA2J_G0022628
 protein coding gene Chr16:33451522-33509481 (+)
FVB/NJ MGP_FVBNJ_G0022603
 protein coding gene Chr16:33481732-33539679 (+)
LP/J MGP_LPJ_G0022696
 protein coding gene Chr16:35002744-35060730 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022622
 protein coding gene Chr16:36775415-36834150 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023223
 protein coding gene Chr16:34787737-34845675 (+)
PWK/PhJ MGP_PWKPhJ_G0021791
 protein coding gene Chr16:33851780-33910741 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021622
 protein coding gene Chr16:34705580-34763516 (+)
WSB/EiJ MGP_WSBEiJ_G0022095
 protein coding gene Chr16:34844935-34902888 (+)



Homology
more
  • Human Ortholog
    GOLGB1, golgin B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOLGB1, golgin B1
  • Synonyms
    GCP, GCP372, GOLIM1
  • Links
    NCBI Gene ID: 2804
    neXtProt AC: NX_Q14789
    UniProt: Q14789

  • Chr Location
    3q13.33; chr3:121663199-121749966 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Golgb1 mouse models

Human Disease Mouse Models
      
IDs
 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects glycosylation of glycoproteins in the extra-cellular matrix of the palatal shelves, resulting in their failure to elevate and fuse, leading to cleft palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    21
  • cDNA Data
    133
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034243 Ensembl Gene Model | MGI Sequence Detail 57946 C57BL/6J ±  kb
    transcript ENSMUST00000039855 Ensembl | MGI Sequence Detail 10847 Not Applicable  
    polypeptide ENSMUSP00000045239 Ensembl | MGI Sequence Detail 3238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR026202 Golgin subfamily B member 1
    • GlyGen
      E9PVZ8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 136
      Genomic 2
      cDNA 133
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925340, MGI:2146577, MGI:2443094, MGI:3779635
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:42083 Diella F, et al., Characterization of the INT6 mammary tumor gene product. DNA Cell Biol. 1997 Jul;16(7):839-47
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory