Shd Gene Detail

Summary

• Symbol
  Shd
• Name
  src homology 2 domain-containing transforming protein D

• Feature Type
  protein coding gene
• IDs
  MGI:1099461
  NCBI Gene: 20420
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr17:56277467-56283625 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 29.09 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  238 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099461	protein coding gene	Chr17:56276828-56283625 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023904	protein coding gene	Chr17:57593019-57599181 (+)
A/J	MGP_AJ_G0023864	protein coding gene	Chr17:56041648-56047798 (+)
AKR/J	MGP_AKRJ_G0023833	protein coding gene	Chr17:56721753-56727903 (+)
BALB/cJ	MGP_BALBcJ_G0023865	protein coding gene	Chr17:55875923-55882084 (+)
C3H/HeJ	MGP_C3HHeJ_G0023628	protein coding gene	Chr17:57432615-57438777 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024309	protein coding gene	Chr17:59876179-59882329 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021756	protein coding gene	Chr17:52560205-52566429 (+)
CAST/EiJ	MGP_CASTEiJ_G0023111	protein coding gene	Chr17:57739743-57746082 (+)
CBA/J	MGP_CBAJ_G0023605	protein coding gene	Chr17:62168575-62174737 (+)
DBA/2J	MGP_DBA2J_G0023733	protein coding gene	Chr17:54776080-54782242 (+)
FVB/NJ	MGP_FVBNJ_G0023699	protein coding gene	Chr17:54292556-54298718 (+)
LP/J	MGP_LPJ_G0023813	protein coding gene	Chr17:58315546-58321708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023726	protein coding gene	Chr17:61740057-61746219 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024354	protein coding gene	Chr17:57102378-57108539 (+)
PWK/PhJ	MGP_PWKPhJ_G0022856	protein coding gene	Chr17:54117732-54124239 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022668	protein coding gene	Chr17:53861849-53868015 (+)
WSB/EiJ	MGP_WSBEiJ_G0023175	protein coding gene	Chr17:57712145-57718301 (+)

Homology

• Human Ortholog
  SHD, Src homology 2 domain containing transforming protein D

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SHD, Src homology 2 domain containing transforming protein D
  
• Links
  HGNC:30633

  NCBI Gene ID: 56961

  neXtProt AC: NX_Q96IW2

  UniProt: Q96IW2

  
  
• Chr Location
  19p13.3; chr19:4279069-4290722 (+)  GRCh38

---

• MGI Vertebrate Homology
  Shd stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: SHD
• Gene Tree
  Shd
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Targeted
  1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  12 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  17
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase shd

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  27
• UniProt
  2
• CCDS
  CCDS50149.1, CCDS89120.1

• Ensembl
  ENSMUSG00000039154 (Evidence)
• NCBI Gene
  20420

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000039154	Ensembl Gene Model | MGI Sequence Detail	6159	C57BL/6J
transcript	ENSMUST00000223629	Ensembl | MGI Sequence Detail	1430	Not Applicable
polypeptide	ENSMUSP00000153605	Ensembl | MGI Sequence Detail	344	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000014838 SH2 domain-containing adapter protein D
  (term hierarchy)
• InterPro Domains
  IPR000980 SH2 domain
  IPR051846 SH2 domain-containing adapter proteins
  IPR036860 SH2 domain superfamily
  IPR035046 SHD, SH2 domain

Molecular
Reagents

• All nucleic 19

  Genomic 2

  cDNA 17

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2146835

References

• Summaries
  All 25

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 2
• Earliest
  J:43082 Oda T, et al., Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene. 1997 Sep;15(11):1255-62
• Latest
  J:317822 Chern T, et al., Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134

TSS for Shd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145263	Chr17:56277451-56277485 (+)	1 bp
Tssr145264	Chr17:56277496-56277577 (+)	70 bp
Tssr145265	Chr17:56277589-56277603 (+)	129 bp
Tssr145266	Chr17:56277646-56277660 (+)	186 bp