She Gene Detail

Summary

• Symbol
  She
• Name
  src homology 2 domain-containing transforming protein E

• Feature Type
  protein coding gene
• IDs
  MGI:1099462
  NCBI Gene: 214547
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr3:89738677-89766141 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 39.19 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  892 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099462	protein coding gene	Chr3:89738667-89766149 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027447	protein coding gene	Chr3:90068341-90096755 (+)
A/J	MGP_AJ_G0027411	protein coding gene	Chr3:87087670-87115074 (+)
AKR/J	MGP_AKRJ_G0027375	protein coding gene	Chr3:89213052-89240167 (+)
BALB/cJ	MGP_BALBcJ_G0027420	protein coding gene	Chr3:87058354-87086362 (+)
C3H/HeJ	MGP_C3HHeJ_G0027162	protein coding gene	Chr3:89395517-89422741 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027866	protein coding gene	Chr3:93456897-93484801 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025218	protein coding gene	Chr3:82576121-82605525 (+)
CAST/EiJ	MGP_CASTEiJ_G0026608	protein coding gene	Chr3:89772318-89804869 (+)
CBA/J	MGP_CBAJ_G0027136	protein coding gene	Chr3:96687978-96715052 (+)
DBA/2J	MGP_DBA2J_G0027274	protein coding gene	Chr3:86466778-86493899 (+)
FVB/NJ	MGP_FVBNJ_G0027242	protein coding gene	Chr3:84800658-84829844 (+)
LP/J	MGP_LPJ_G0027383	protein coding gene	Chr3:91141996-91172710 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027262	protein coding gene	Chr3:102868615-102898535 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027925	protein coding gene	Chr3:88952738-88980286 (+)
PWK/PhJ	MGP_PWKPhJ_G0026342	protein coding gene	Chr3:86351208-86381251 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026161	protein coding gene	Chr3:88138761-88170221 (+)
WSB/EiJ	MGP_WSBEiJ_G0026690	protein coding gene	Chr3:89354285-89382063 (+)

Homology

• Human Ortholog
  SHE, Src homology 2 domain containing E

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SHE, Src homology 2 domain containing E
  
• Links
  HGNC:27004

  NCBI Gene ID: 126669

  neXtProt AC: NX_Q5VZ18

  UniProt: Q5VZ18

  
  
• Chr Location
  1q21.3; chr1:154469637-154502412 (-)  GRCh38

---

• MGI Vertebrate Homology
  She stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SHE
• Gene Tree
  She
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotype references
  

• All Mutations and Alleles
  13
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  6
• Radiation induced
  1
• Targeted
  4
• Genomic Mutations
  2 involving She
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  22 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  733
• Tissues
  4
• cDNA Data
  13
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase she
  ZFIN she

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  4
• UniProt
  2
• CCDS
  CCDS17518.1

• Ensembl
  ENSMUSG00000046280 (Evidence)
• NCBI Gene
  214547

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046280	Ensembl Gene Model | MGI Sequence Detail	27465	C57BL/6J
transcript	ENSMUST00000050401	Ensembl | MGI Sequence Detail	5733	Not Applicable
polypeptide	ENSMUSP00000059658	Ensembl | MGI Sequence Detail	492	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000030650 SH2 domain-containing adapter protein E
  (term hierarchy)
• InterPro Domains
  IPR000980 SH2 domain
  IPR051846 SH2 domain-containing adapter proteins
  IPR036860 SH2 domain superfamily
  IPR035042 SHE, SH2 domain

Molecular
Reagents

• All nucleic 13

  cDNA 13

  
  

  Microarray probesets 4

References

• Summaries
  All 32

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 1

  Phenotypes 11
• Earliest
  J:43082 Oda T, et al., Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene. 1997 Sep;15(11):1255-62
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for She:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30140	Chr3:89738659-89738691 (+)	-2 bp
Tssr30141	Chr3:89738702-89738713 (+)	31 bp