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Dhx15 Gene Detail
Summary
  • Symbol
    Dhx15
  • Name
    DEAH-box helicase 15
  • Synonyms
    DBP1, Ddx15, DEAH (Asp-Glu-Ala-His) box polypeptide 15, HRH2, mDEAH9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099786
    NCBI Gene: 13204
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52307545-52347856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 27.51 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    797 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099786
 protein coding gene Chr5:52307545-52347888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029543
 protein coding gene Chr5:51107592-51149208 (-)
A/J MGP_AJ_G0029511
 protein coding gene Chr5:49322780-49363088 (-)
AKR/J MGP_AKRJ_G0029459
 protein coding gene Chr5:50989720-51030296 (-)
BALB/cJ MGP_BALBcJ_G0029520
 protein coding gene Chr5:49789176-49829336 (-)
C3H/HeJ MGP_C3HHeJ_G0029243
 protein coding gene Chr5:51164186-51204325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029974
 protein coding gene Chr5:53247038-53289825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027214
 protein coding gene Chr5:46102967-46144880 (-)
CAST/EiJ MGP_CASTEiJ_G0028651
 protein coding gene Chr5:50155725-50196892 (-)
CBA/J MGP_CBAJ_G0029212
 protein coding gene Chr5:54878450-54918513 (-)
DBA/2J MGP_DBA2J_G0029358
 protein coding gene Chr5:49382916-49423427 (-)
FVB/NJ MGP_FVBNJ_G0029318
 protein coding gene Chr5:48724628-48767003 (-)
LP/J MGP_LPJ_G0029443
 protein coding gene Chr5:51572672-51612967 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029346
 protein coding gene Chr5:55989690-56031118 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030007
 protein coding gene Chr5:50490608-50530902 (-)
PWK/PhJ MGP_PWKPhJ_G0028375
 protein coding gene Chr5:48443697-48484770 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028209
 protein coding gene Chr5:49923347-49968360 (-)
WSB/EiJ MGP_WSBEiJ_G0028732
 protein coding gene Chr5:50530794-50571088 (-)



Homology
more
  • Human Ortholog
    DHX15, DEAH-box helicase 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX15, DEAH-box helicase 15
  • Synonyms
    DBP1, DDX15, hPrp43, PRP43, PRPF43, PrPp43p
  • Links
    NCBI Gene ID: 1665
    neXtProt AC: NX_O43143
    UniProt: O43143

  • Chr Location
    4p15.2; chr4:24517441-24584554 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    15
  • cDNA Data
    290
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029169 Ensembl Gene Model | MGI Sequence Detail 40312 C57BL/6J ±  kb
    transcript ENSMUST00000031061 Ensembl | MGI Sequence Detail 3010 Not Applicable  
    polypeptide ENSMUSP00000031061 Ensembl | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000029412 ATP-dependent RNA helicase DHX15
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR011545 DEAD/DEAH box helicase domain
      IPR044756 DHX15, DEXH-box helicase domain
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      O35286 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 291
      cDNA 290
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 34
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory