Nrp2 Gene Detail

Summary

• Symbol
  Nrp2
• Name
  neuropilin 2
• Synonyms
  1110048P06Rik, NP-2, NP2, Npn-2, Npn2

• Feature Type
  protein coding gene
• IDs
  MGI:1100492
  NCBI Gene: 18187
• Alliance
  gene page
• Transcription Start Sites
  63 TSS

Location &
Maps

• Sequence Map
  Chr1:62742476-62857851 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 31.35 cM, cytoband C2
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  2392 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100492	protein coding gene	Chr1:62742444-62857854 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016083	protein coding gene	Chr1:62822120-62945321 (+)
A/J	MGP_AJ_G0016066	protein coding gene	Chr1:60601175-60717953 (+)
AKR/J	MGP_AKRJ_G0016023	protein coding gene	Chr1:62278197-62396128 (+)
BALB/cJ	MGP_BALBcJ_G0016021	protein coding gene	Chr1:60672066-60792578 (+)
C3H/HeJ	MGP_C3HHeJ_G0015853	protein coding gene	Chr1:62539847-62660116 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016474	protein coding gene	Chr1:65236528-65366416 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014195	protein coding gene	Chr1:56731784-56847198 (+)
CAST/EiJ	MGP_CASTEiJ_G0015436	protein coding gene	Chr1:61789082-61913504 (+)
CBA/J	MGP_CBAJ_G0015825	protein coding gene	Chr1:67321864-67448519 (+)
DBA/2J	MGP_DBA2J_G0015926	protein coding gene	Chr1:60012170-60128818 (+)
FVB/NJ	MGP_FVBNJ_G0015929	protein coding gene	Chr1:59313604-59430548 (+)
LP/J	MGP_LPJ_G0015998	protein coding gene	Chr1:63709574-63830727 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015949	protein coding gene	Chr1:70242905-70365650 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016521	protein coding gene	Chr1:62245087-62363619 (+)
PWK/PhJ	MGP_PWKPhJ_G0015223	protein coding gene	Chr1:59384783-59501168 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015002	protein coding gene	Chr1:61748826-61867477 (+)
WSB/EiJ	MGP_WSBEiJ_G0015498	protein coding gene	Chr1:61970031-62098949 (+)

Homology

• Human Ortholog
  NRP2, neuropilin 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  NRP2, neuropilin 2
  
• Synonyms
  NP2, NPN2, PRO2714, VEGF165R2
• Links
  HGNC:8005

  NCBI Gene ID: 8828

  neXtProt AC: NX_O60462

  UniProt: O60462

  
  
• Chr Location
  2q33.3; chr2:205681990-205798133 (+)  GRCh38

---

• MGI Vertebrate Homology
  Nrp2 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: NRP2
• Protein SuperFamily
  Neuropilin
• Gene Tree
  Nrp2
  

Human Diseases

• Diseases
  1 with Nrp2 mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

autism spectrum disorder      

DOID:0060041
MESH:D000067877

View 1 model

Mouse Models

Human Disease Modeled: autism spectrum disorder

Allelic Composition	Genetic Background	Reference	Phenotypes
Nrp2tm1.2Mom/Nrp2tm1.2Mom	involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ	J:166116	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  43 phenotypes from 5 alleles in 9 genetic backgrounds
  16 phenotypes from multigenic genotypes
  4 images
  101 phenotype references
  

• All Mutations and Alleles
  30
• Chemically induced (other)
  1
• Endonuclease-mediated
  6
• Gene trapped
  15
• Radiation induced
  1
• Targeted
  7
• Genomic Mutations
  2 involving Nrp2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  89 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  46
• GO References
  19

Expression

• Assay Results
  1240
• Tissues
  284
• cDNA Data
  84
• Literature Summary
  244

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA NRP2
  Xenbase nrp2
  ZFIN nrp2a, nrp2b

Sequences &
Gene Models

• All Sequences
  78
• RefSeq
  12
• UniProt
  6
• CCDS
  CCDS14995.1, CCDS35589.1, CCDS35590.1, CCDS35591.1, CCDS35592.1, CCDS35593.1

• Ensembl
  ENSMUSG00000025969 (Evidence)
• NCBI Gene
  18187

Representative Sequences			Length	Strain/Species
genomic	18187	NCBI Gene Model | MGI Sequence Detail	115376	C57BL/6J
transcript	NM_001077403	RefSeq | MGI Sequence Detail	6739	C57BL/6
polypeptide	O35375	UniProt | EBI | MGI Sequence Detail	931	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000011436 neuropilin-2
  (term hierarchy)
• InterPro Domains
  IPR000421 Coagulation factor 5/8 C-terminal domain
  IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
  IPR000859 CUB domain
  IPR008979 Galactose-binding-like domain superfamily
  IPR000998 MAM domain
  IPR051560 MAM domain-containing protein
  IPR014648 Neuropilin
  IPR022579 Neuropilin, C-terminal
  IPR050633 Neuropilin/Multicopper Oxidase/Coagulation Factor
  IPR035914 Spermadhesin, CUB domain superfamily
• GlyGen
  O35375 4 sites, 1 N-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 116

  cDNA 88

  Primer pair 8

  Other 20

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1916002

References

• Summaries
  All 345

  Developmental Gene Expression 244

  Diseases 1

  Gene Ontology 19

  Phenotypes 101
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:354188 Vallecillo-Garcia P, et al., Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development. 2024 Sep 1;151(17):dev202747

TSS for Nrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6982	Chr1:62742466-62742476 (+)	-5 bp
Tssr6983	Chr1:62742491-62742510 (+)	25 bp
Tssr6984	Chr1:62742541-62742558 (+)	74 bp
Tssr6985	Chr1:62742587-62742598 (+)	117 bp
Tssr6986	Chr1:62742601-62742616 (+)	133 bp
Tssr6987	Chr1:62742826-62742861 (+)	368 bp
Tssr6988	Chr1:62743075-62743093 (+)	608 bp
Tssr6989	Chr1:62743105-62743141 (+)	647 bp
Tssr6990	Chr1:62743146-62743157 (+)	676 bp
Tssr6991	Chr1:62745485-62745509 (+)	3,021 bp
Tssr6992	Chr1:62747959-62747988 (+)	5,498 bp
Tssr6993	Chr1:62748195-62748208 (+)	5,726 bp
Tssr6994	Chr1:62750842-62750849 (+)	8,370 bp
Tssr6995	Chr1:62758075-62758086 (+)	15,605 bp
Tssr6996	Chr1:62758141-62758166 (+)	15,678 bp
Tssr6997	Chr1:62758177-62758206 (+)	15,716 bp
Tssr6998	Chr1:62764955-62764969 (+)	22,486 bp
Tssr6999	Chr1:62765174-62765193 (+)	22,708 bp
Tssr7000	Chr1:62765470-62765481 (+)	23,000 bp
Tssr7001	Chr1:62765556-62765567 (+)	23,086 bp
Tssr7002	Chr1:62765637-62765653 (+)	23,169 bp
Tssr7003	Chr1:62765669-62765701 (+)	23,209 bp
Tssr7004	Chr1:62765824-62765883 (+)	23,378 bp
Tssr7005	Chr1:62765884-62765942 (+)	23,437 bp
Tssr7006	Chr1:62766012-62766102 (+)	23,581 bp
Tssr7007	Chr1:62766109-62766127 (+)	23,642 bp
Tssr7008	Chr1:62766132-62766161 (+)	23,671 bp
Tssr7009	Chr1:62766181-62766231 (+)	23,730 bp
Tssr7010	Chr1:62766280-62766301 (+)	23,815 bp
Tssr7011	Chr1:62766324-62766336 (+)	23,854 bp
Tssr7012	Chr1:62769465-62769480 (+)	26,997 bp
Tssr7013	Chr1:62769487-62769502 (+)	27,019 bp
Tssr7014	Chr1:62774563-62774585 (+)	32,098 bp
Tssr7015	Chr1:62777508-62777538 (+)	35,047 bp
Tssr7016	Chr1:62777562-62777577 (+)	35,094 bp
Tssr7017	Chr1:62777586-62777602 (+)	35,118 bp
Tssr7018	Chr1:62782733-62782761 (+)	40,271 bp
Tssr7019	Chr1:62789531-62789537 (+)	47,058 bp
Tssr7020	Chr1:62793984-62794001 (+)	51,517 bp
Tssr7021	Chr1:62797422-62797438 (+)	54,954 bp
Tssr7022	Chr1:62802108-62802121 (+)	59,639 bp
Tssr7023	Chr1:62803752-62803756 (+)	61,278 bp
Tssr7024	Chr1:62808127-62808162 (+)	65,669 bp
Tssr7025	Chr1:62808166-62808181 (+)	65,698 bp
Tssr7026	Chr1:62810086-62810096 (+)	67,615 bp
Tssr7027	Chr1:62817216-62817254 (+)	74,759 bp
Tssr7028	Chr1:62831566-62831611 (+)	89,113 bp
Tssr7029	Chr1:62834702-62834733 (+)	92,242 bp
Tssr7030	Chr1:62835128-62835143 (+)	92,660 bp
Tssr7031	Chr1:62835145-62835159 (+)	92,676 bp
Tssr7032	Chr1:62835191-62835237 (+)	92,738 bp
Tssr7033	Chr1:62835270-62835359 (+)	92,839 bp
Tssr7034	Chr1:62835377-62835388 (+)	92,907 bp
Tssr7035	Chr1:62835448-62835453 (+)	92,975 bp
Tssr7036	Chr1:62836450-62836469 (+)	93,984 bp
Tssr7037	Chr1:62837256-62837310 (+)	94,807 bp
Tssr7038	Chr1:62837360-62837374 (+)	94,891 bp
Tssr7039	Chr1:62837434-62837456 (+)	94,969 bp
Tssr7040	Chr1:62837558-62837570 (+)	95,088 bp
Tssr7044	Chr1:62855458-62855479 (+)	112,993 bp
Tssr7045	Chr1:62855813-62855825 (+)	113,343 bp
Tssr7046	Chr1:62855972-62855985 (+)	113,503 bp
Tssr7047	Chr1:62857400-62857422 (+)	114,935 bp