Kcnk3 MGI Mouse Gene Detail - MGI:1100509 - potassium channel, subfamily K, member 3

Symbol

Kcnk3
Name

potassium channel, subfamily K, member 3
Synonyms

cTBAK-1, Task-1

Feature Type

protein coding gene
IDs

MGI:1100509
NCBI Gene: 16527
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr5:30745514-30782614 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.68 cM, cytoband B
Mapping Data

6 experiments

SNPs within 2kb

785 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100509	protein coding gene	Chr5:30745514-30782615 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029392	protein coding gene	Chr5:28541572-28581540 (+)
A/J	MGP_AJ_G0029358	protein coding gene	Chr5:27603345-27642218 (+)
AKR/J	MGP_AKRJ_G0029309	protein coding gene	Chr5:28751394-28790545 (+)
BALB/cJ	MGP_BALBcJ_G0029369	protein coding gene	Chr5:28131367-28169340 (+)
C3H/HeJ	MGP_C3HHeJ_G0029090	protein coding gene	Chr5:28748193-28787715 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029822	protein coding gene	Chr5:30281708-30318429 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027060	protein coding gene	Chr5:25093503-25131154 (+)
CAST/EiJ	MGP_CASTEiJ_G0028501	protein coding gene	Chr5:27845781-27883639 (+)
CBA/J	MGP_CBAJ_G0029058	protein coding gene	Chr5:30879109-30916647 (+)
DBA/2J	MGP_DBA2J_G0029207	protein coding gene	Chr5:27792567-27829676 (+)
FVB/NJ	MGP_FVBNJ_G0029165	protein coding gene	Chr5:27202132-27241892 (+)
LP/J	MGP_LPJ_G0029292	protein coding gene	Chr5:28992159-29034694 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029194	protein coding gene	Chr5:31770644-31808528 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029856	protein coding gene	Chr5:28254025-28292531 (+)
PWK/PhJ	MGP_PWKPhJ_G0028225	protein coding gene	Chr5:26905646-26943543 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028056	protein coding gene	Chr5:27601576-27637877 (+)
WSB/EiJ	MGP_WSBEiJ_G0028581	protein coding gene	Chr5:28326952-28365104 (+)

Human Ortholog

KCNK3, potassium two pore domain channel subfamily K member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNK3, potassium two pore domain channel subfamily K member 3
Synonyms

K2p3.1, OAT1, PPH4, TASK, TASK-1, TASK1, TBAK1
Links

HGNC:6278

NCBI Gene ID: 3777

neXtProt AC: NX_O14649

UniProt: O14649
Chr Location

2p23.3; chr2:26692722-26733420 (+) GRCh38

MGI Vertebrate Homology

Kcnk3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNK3
Protein SuperFamily

K_channel_subfamily_K_type
Gene Tree

Kcnk3

Diseases

1 with human KCNK3 associations

				Human Disease	Mouse Models
				primary pulmonary hypertension IDs primary pulmonary hypertension DOID:14557 ICD10CM:I27.0 ICD9CM:416.0 OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344 ORDO:422 UMLS_CUI:C0152171

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
10 phenotypes from multigenic genotypes
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

3
Spontaneous

1
Targeted

6
Genomic Mutations

6 involving Kcnk3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

26
cDNA Data

28
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnk3

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS19160.1

Ensembl

ENSMUSG00000049265 (Evidence)
NCBI Gene

16527

			Length	Strain/Species	Flank
genomic	16527	NCBI Gene Model \| MGI Sequence Detail	37101	C57BL/6J	± kb
transcript	NM_010608	RefSeq \| MGI Sequence Detail	3810	ZRU/MplStud
polypeptide	O35111	UniProt \| EBI \| MGI Sequence Detail	409	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002076 potassium channel subfamily K member 3

(term hierarchy)
InterPro Domains

IPR013099 Potassium channel domain

IPR005406 Potassium channel subfamily K member 3

IPR003280 Two pore domain potassium channel

IPR003092 Two pore domain potassium channel, TASK family
GlyGen

O35111 1 site, 1 N-linked glycan (1 site)

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All nucleic 35

Genomic 1

cDNA 30

Primer pair 4

Microarray probesets 6

Summaries

All 109

Developmental Gene Expression 8

Diseases 2

Gene Ontology 10

Phenotypes 67
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345156 Wang Z, et al., Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism. Front Physiol. 2023;14:1136574

TSS for Kcnk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45584	Chr5:30744737-30744750 (+)	-770 bp
Tssr45585	Chr5:30745384-30745395 (+)	-124 bp
Tssr45586	Chr5:30745422-30745515 (+)	-45 bp
Tssr45587	Chr5:30745518-30745529 (+)	10 bp
Tssr45588	Chr5:30745534-30745564 (+)	35 bp
Tssr45589	Chr5:30747400-30747413 (+)	1,893 bp
Tssr45590	Chr5:30753350-30753368 (+)	7,845 bp
Tssr45591	Chr5:30779384-30779399 (+)	33,878 bp
Tssr45592	Chr5:30779797-30779811 (+)	34,290 bp
Tssr45593	Chr5:30779848-30779871 (+)	34,346 bp
Tssr45594	Chr5:30780037-30780048 (+)	34,529 bp
Tssr45595	Chr5:30780287-30780298 (+)	34,779 bp
Tssr45596	Chr5:30780505-30780527 (+)	35,002 bp
Tssr45597	Chr5:30780537-30780550 (+)	35,030 bp
Tssr45598	Chr5:30780627-30780653 (+)	35,126 bp
Tssr45599	Chr5:30780838-30780875 (+)	35,343 bp
Tssr45600	Chr5:30781181-30781188 (+)	35,671 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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