Clpb MGI Mouse Gene Detail - MGI:1100517 - ClpB caseinolytic peptidase B

Symbol

Clpb
Name

ClpB caseinolytic peptidase B
Synonyms

Skd3

Feature Type

protein coding gene
IDs

MGI:1100517
NCBI Gene: 20480
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:101312958-101444667 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.63 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

2719 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100517	protein coding gene	Chr7:101312840-101444713 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032586	protein coding gene	Chr7:104669135-104798524 (+)
A/J	MGP_AJ_G0032562	protein coding gene	Chr7:102002818-102130824 (+)
AKR/J	MGP_AKRJ_G0032498	protein coding gene	Chr7:104444924-104577115 (+)
BALB/cJ	MGP_BALBcJ_G0032573	protein coding gene	Chr7:101701583-101828177 (+)
C3H/HeJ	MGP_C3HHeJ_G0032287	protein coding gene	Chr7:104822052-104949821 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033070	protein coding gene	Chr7:108604533-108733467 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030064	protein coding gene	Chr7:104359636-104486915 (+)
CAST/EiJ	MGP_CASTEiJ_G0031613	protein coding gene	Chr7:96368233-96497144 (+)
CBA/J	MGP_CBAJ_G0032253	protein coding gene	Chr7:112376779-112507874 (+)
DBA/2J	MGP_DBA2J_G0032405	protein coding gene	Chr7:100333853-100461469 (+)
FVB/NJ	MGP_FVBNJ_G0032361	protein coding gene	Chr7:100108907-100239226 (+)
LP/J	MGP_LPJ_G0032494	protein coding gene	Chr7:105984133-106112888 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032395	protein coding gene	Chr7:113717470-113848293 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033092	protein coding gene	Chr7:103710886-103838462 (+)
PWK/PhJ	MGP_PWKPhJ_G0031331	protein coding gene	Chr7:93442161-93569762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031175	protein coding gene	Chr7:90987439-91116937 (+)
WSB/EiJ	MGP_WSBEiJ_G0031730	protein coding gene	Chr7:104399686-104528785 (+)

Human Ortholog

CLPB, ClpB family mitochondrial disaggregase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLPB, ClpB family mitochondrial disaggregase
Synonyms

ANKCLB, ANKCLP, HSP78, MEGCANN, MGCA7, MGCA7A, SCN9, SKD3
Links

HGNC:30664

NCBI Gene ID: 81570

neXtProt AC: NX_Q9H078

UniProt: Q9H078
Chr Location

11q13.4; chr11:72285495-72434680 (-) GRCh38

MGI Vertebrate Homology

Clpb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLPB
Gene Tree

Clpb

Diseases

3 with human CLPB associations

				Human Disease	Mouse Models
				3-methylglutaconic aciduria type 7a IDs 3-methylglutaconic aciduria type 7a DOID:0081133 OMIM:619835
				3-methylglutaconic aciduria type 7b IDs 3-methylglutaconic aciduria type 7b DOID:0081134 OMIM:616271
				severe congenital neutropenia IDs severe congenital neutropenia DOID:0050590 ICD10CM:D70 OMIM:PS202700 ORDO:42738

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Clpb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

22
cDNA Data

109
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clpb

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All Sequences

84
RefSeq

16
UniProt

9
CCDS

CCDS21513.1, CCDS90284.1

Ensembl

ENSMUSG00000001829 (Evidence)
NCBI Gene

20480

			Length	Strain/Species	Flank
genomic	20480	NCBI Gene Model \| MGI Sequence Detail	131710	C57BL/6J	± kb
transcript	NR_184442	RefSeq \| MGI Sequence Detail	4693	C57BL/6
polypeptide	Q60649	UniProt \| EBI \| MGI Sequence Detail	677	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000005599 caseinolytic peptidase B protein

(term hierarchy)
EC

3.6.1.-
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR003959 ATPase, AAA-type, core

IPR050130 ATP-dependent Clp protease/Chaperone ClpA/ClpB

IPR001270 ClpA/B family

IPR019489 Clp ATPase, C-terminal

IPR050842 Cul2-RING E3 Ligase Substrate-Recognition Fem-1

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 113

cDNA 113

Microarray probesets 6

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MGI:3034703

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 16
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Clpb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68257	Chr7:101312810-101312820 (+)	-143 bp
Tssr68258	Chr7:101312821-101312824 (+)	-135 bp
Tssr68259	Chr7:101312842-101312886 (+)	-94 bp
Tssr68260	Chr7:101312934-101312941 (+)	-20 bp
Tssr68261	Chr7:101312948-101312997 (+)	15 bp
Tssr68262	Chr7:101412724-101412731 (+)	99,770 bp
Tssr68263	Chr7:101414699-101414700 (+)	101,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24