Myt1 MGI Mouse Gene Detail - MGI:1100535 - myelin transcription factor 1

Symbol

Myt1
Name

myelin transcription factor 1
Synonyms

mKIAA0835, Nzf2, NZF-2a, NZF-2b, Nztf2

Feature Type

protein coding gene
IDs

MGI:1100535
NCBI Gene: 17932
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:181405125-181469590 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.77 cM
Mapping Data

5 experiments

SNPs within 2kb

982 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100535	protein coding gene	Chr2:181405099-181469590 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027037	protein coding gene	Chr2:188386420-188457804 (+)
A/J	MGP_AJ_G0027003	protein coding gene	Chr2:180612766-180679301 (+)
AKR/J	MGP_AKRJ_G0026973	protein coding gene	Chr2:186034923-186106715 (+)
BALB/cJ	MGP_BALBcJ_G0027011	protein coding gene	Chr2:181097409-181162412 (+)
C3H/HeJ	MGP_C3HHeJ_G0026753	protein coding gene	Chr2:186377270-186445797 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027457	protein coding gene	Chr2:193824272-193898961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024821	protein coding gene	Chr2:171296236-171361954 (+)
CAST/EiJ	MGP_CASTEiJ_G0026212	protein coding gene	Chr2:184663221-184732411 (+)
CBA/J	MGP_CBAJ_G0026730	protein coding gene	Chr2:200861055-200938644 (+)
DBA/2J	MGP_DBA2J_G0026867	protein coding gene	Chr2:179715761-179785108 (+)
FVB/NJ	MGP_FVBNJ_G0026833	protein coding gene	Chr2:178341976-178410028 (+)
LP/J	MGP_LPJ_G0026969	protein coding gene	Chr2:188404686-188476939 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026853	protein coding gene	Chr2:203398912-203469670 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027517	protein coding gene	Chr2:186017247-186083036 (+)
PWK/PhJ	MGP_PWKPhJ_G0025948	protein coding gene	Chr2:177247594-177313445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025748	protein coding gene	Chr2:182507722-182571950 (+)
WSB/EiJ	MGP_WSBEiJ_G0026284	protein coding gene	Chr2:186990309-187060952 (+)

Human Ortholog

MYT1, myelin transcription factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYT1, myelin transcription factor 1
Synonyms

C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2H2C1, ZC2HC4A
Links

HGNC:7622

NCBI Gene ID: 4661

neXtProt AC: NX_Q01538

UniProt: Q01538
Chr Location

20q13.33; chr20:64102394-64242253 (+) GRCh38

MGI Vertebrate Homology

Myt1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYT1
Gene Tree

Myt1

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Phenotype Summary

11 phenotypes from 4 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1053
Tissues

165
cDNA Data

17
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYT1

Xenbase myt1

ZFIN myt1a, myt1b

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All Sequences

94
RefSeq

37
UniProt

7
CCDS

CCDS17223.1, CCDS50856.1, CCDS50857.1

Ensembl

ENSMUSG00000010505 (Evidence)
NCBI Gene

17932

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010505	Ensembl Gene Model \| MGI Sequence Detail	64466	C57BL/6J	± kb
transcript	ENSMUST00000081125	Ensembl \| MGI Sequence Detail	5327	Not Applicable
polypeptide	ENSMUSP00000079900	Ensembl \| MGI Sequence Detail	1169	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010892 myelin transcription factor 1

(term hierarchy)
PDB

2JX1, 2JYD, 2MF8
InterPro Domains

IPR013681 Myelin transcription factor 1

IPR002515 Zinc finger, C2H2C-type

IPR036060 Zinc finger, C2H2C-type superfamily
GlyGen

Q8CFC2 1 site, 1 N-linked glycan (1 site)

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All nucleic 27

cDNA 18

Primer pair 9

Microarray probesets 4

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MGD-MRK-38473, MGI:109428

Summaries

All 66

Developmental Gene Expression 34

Gene Ontology 8

Phenotypes 9
Earliest

J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
Latest

J:354180 Xu M, et al., ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)

TSS for Myt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22342	Chr2:181405108-181405128 (+)	-7 bp
Tssr22343	Chr2:181408798-181408830 (+)	3,689 bp
Tssr22344	Chr2:181408833-181408866 (+)	3,725 bp
Tssr22345	Chr2:181408910-181408922 (+)	3,791 bp
Tssr22346	Chr2:181409076-181409114 (+)	3,970 bp
Tssr22347	Chr2:181409136-181409178 (+)	4,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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