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Aff1 Gene Detail
Summary
  • Symbol
    Aff1
  • Name
    AF4/FMR2 family, member 1
  • Synonyms
    9630032B01Rik, Af4, Mllt2h, Rob
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100819
    NCBI Gene: 17355
  • Alliance
    genome feature page
  • Transcription Start Sites
    47 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:103840307-104003188 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.45 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4689 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100819
 protein coding gene Chr5:103840240-104003188 (+)
129S1/SvImJ ENSMUSG00200006040
 protein coding gene Chr5:97558919-97722872 (+)
A/J ENSMUSG00195031620
 protein coding gene Chr5:97166392-97329595 (+)
AKR/J ENSMUSG00220036355
 protein coding gene Chr5:96620115-96784328 (+)
BALB/cJ ENSMUSG00180032994
 protein coding gene Chr5:97318599-97481780 (+)
C3H/HeJ ENSMUSG00175032507
 protein coding gene Chr5:99393619-99558369 (+)
C57BL/6NJ ENSMUSG00215010089
 protein coding gene Chr5:97230755-97393908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027469
 protein coding gene Chr5:96523019-96685957 (+)
CAST/EiJ ENSTCUG00005022000
 protein coding gene Chr5:96591303-96693084 (+)
CBA/J ENSMUSG00210030024
 protein coding gene Chr5:98143901-98308669 (+)
DBA/2J ENSMUSG00185041028
 protein coding gene Chr5:101063200-101227139 (+)
FVB/NJ ENSMUSG00205027118
 protein coding gene Chr5:97063296-97228046 (+)
JF1/MsJ ENSUMUG00000006127
 protein coding gene Chr5:104004800-104170040 (+)
LP/J ENSMUSG00230025188
 protein coding gene Chr5:105100321-105264246 (+)
NOD/ShiLtJ ENSMUSG00190023030
 protein coding gene Chr5:97037089-97201258 (+)
NZO/HlLtJ ENSMUSG00225024673
 protein coding gene Chr5:112856708-113019396 (+)
PWK/PhJ ENSLUMG00010013660
 protein coding gene Chr5:96187501-96289182 (+)
SPRET/EiJ ENSMSPG00010023638
 protein coding gene Chr5:99116644-99218106 (+)
WSB/EiJ ENSIUOG00005029632
 protein coding gene Chr5:99743311-99906638 (+)



Homology
more
  • Human Ortholog
    AFF1, ALF transcription elongation factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFF1, ALF transcription elongation factor 1
  • Synonyms
    AF4, FEL, MLLT2, PBM1
  • Links
    NCBI Gene ID: 4299
    UniProt: P51825

  • Chr Location
    4q21.3-q22.1; chr4:86934237-87141073 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired B and T cell development. Heterozygotes for an ENU-induced mutation exhibit small size, ataxia, adult-onset Purkinje cell loss, cataracts, reduced survival, and low fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    222
  • cDNA Data
    30
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17355 NCBI Gene Model | MGI Sequence Detail 162882 C57BL/6J ±  kb
    transcript NM_001080798 RefSeq | MGI Sequence Detail 8412 ZRU/MplStud  
    polypeptide O88573 UniProt | EBI | MGI Sequence Detail 1216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1861996, MGI:2141185, MGI:2442389
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:327031 Tran TM, et al., The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis. Leukemia. 2022 Jan;36(1):68-79
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory