Kpna3 MGI Mouse Gene Detail - MGI:1100863 - karyopherin subunit alpha 3

Symbol

Kpna3
Name

karyopherin subunit alpha 3
Synonyms

importin alpha 4, IPOA4

Feature Type

protein coding gene
IDs

MGI:1100863
NCBI Gene: 16648
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr14:61602660-61677323 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 32.76 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

1272 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100863	protein coding gene	Chr14:61602635-61677396 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021441	protein coding gene	Chr14:55745325-55826086 (-)
A/J	MGP_AJ_G0021400	protein coding gene	Chr14:54524552-54598414 (-)
AKR/J	MGP_AKRJ_G0021375	protein coding gene	Chr14:56467394-56551916 (-)
BALB/cJ	MGP_BALBcJ_G0021405	protein coding gene	Chr14:54487416-54563058 (-)
C3H/HeJ	MGP_C3HHeJ_G0021183	protein coding gene	Chr14:56113348-56188898 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021844	protein coding gene	Chr14:58460562-58542766 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019384	protein coding gene	Chr14:52527517-52603542 (-)
CAST/EiJ	MGP_CASTEiJ_G0020699	protein coding gene	Chr14:52502204-52581336 (-)
CBA/J	MGP_CBAJ_G0021150	protein coding gene	Chr14:60137047-60223242 (-)
DBA/2J	MGP_DBA2J_G0021273	protein coding gene	Chr14:54195285-54269437 (-)
FVB/NJ	MGP_FVBNJ_G0021251	protein coding gene	Chr14:53620457-53694303 (-)
LP/J	MGP_LPJ_G0021347	protein coding gene	Chr14:56781273-56859576 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021280	protein coding gene	Chr14:59449288-59532441 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021867	protein coding gene	Chr14:55622904-55702618 (-)
PWK/PhJ	MGP_PWKPhJ_G0020443	protein coding gene	Chr14:50862685-50940033 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020276	protein coding gene	Chr14:51556009-51633396 (-)
WSB/EiJ	MGP_WSBEiJ_G0020752	protein coding gene	Chr14:55942013-56022993 (-)

Human Ortholog

KPNA3, karyopherin subunit alpha 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KPNA3, karyopherin subunit alpha 3
Synonyms

hSRP1, IPOA4, SPG88, SRP1, SRP1gamma, SRP4
Links

HGNC:6396

NCBI Gene ID: 3839

neXtProt AC: NX_O00505

UniProt: O00505
Chr Location

13q14.2; chr13:49699320-49792682 (-) GRCh38

MGI Vertebrate Homology

Kpna3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KPNA3
Protein SuperFamily

Importin_alpha
Gene Tree

Kpna3

Diseases

1 with human KPNA3 associations

				Human Disease	Mouse Models
				hereditary spastic paraplegia 88 IDs hereditary spastic paraplegia 88 DOID:0070457 OMIM:620106

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
15 phenotype references

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

20
Targeted

3
Genomic Mutations

1 involving Kpna3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a null mutation are viable and fertile. Homozygous knockout leads to increased susceptibility to influenza A virus-induced morbidity and mortality.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

35
cDNA Data

199
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KPNA3

Xenbase kpna3

ZFIN kpna3

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS36942.1

Ensembl

ENSMUSG00000021929 (Evidence)
NCBI Gene

16648

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021929	Ensembl Gene Model \| MGI Sequence Detail	74664	C57BL/6J	± kb
transcript	ENSMUST00000022496	Ensembl \| MGI Sequence Detail	4069	Not Applicable
polypeptide	ENSMUSP00000022496	Ensembl \| MGI Sequence Detail	521	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009434 importin subunit alpha-4

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR032413 Atypical Arm repeat

IPR002652 Importin-alpha, importin-beta-binding domain

IPR036975 Importin-alpha, importin-beta-binding domain superfamily

IPR024931 Importin subunit alpha
GlyGen

O35344 1 site, 1 N-linked glycan (1 site)

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All nucleic 201

cDNA 199

Primer pair 2

Microarray probesets 6

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 15
Earliest

J:43573 Tsuji L, et al., Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 1997 Oct 13;416(1):30-4
Latest

J:330233 Aomine Y, et al., Importin alpha3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice. Front Neurosci. 2022;16:905991

TSS for Kpna3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129082	Chr14:61677512-61677551 (-)	-209 bp
Tssr129081	Chr14:61677474-61677490 (-)	-159 bp
Tssr129080	Chr14:61677280-61677318 (-)	24 bp
Tssr129079	Chr14:61677258-61677277 (-)	55 bp
Tssr129078	Chr14:61675780-61675783 (-)	1,541 bp
Tssr129077	Chr14:61674497-61674503 (-)	2,823 bp
Tssr129076	Chr14:61674248-61674259 (-)	3,069 bp
Tssr129075	Chr14:61658286-61658289 (-)	19,035 bp
Tssr129074	Chr14:61657150-61657156 (-)	20,170 bp
Tssr129073	Chr14:61648515-61648553 (-)	28,789 bp
Tssr129072	Chr14:61611771-61611789 (-)	65,543 bp
Tssr129071	Chr14:61608344-61608374 (-)	68,964 bp
Tssr129070	Chr14:61608206-61608221 (-)	69,109 bp
Tssr129069	Chr14:61608181-61608203 (-)	69,131 bp
Tssr129068	Chr14:61607963-61607980 (-)	69,351 bp
Tssr129067	Chr14:61607892-61607929 (-)	69,412 bp
Tssr129066	Chr14:61604118-61604133 (-)	73,197 bp
Tssr129065	Chr14:61604069-61604091 (-)	73,243 bp
Tssr129064	Chr14:61602962-61602981 (-)	74,351 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24