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Dnah11 Gene Detail
Summary
  • Symbol
    Dnah11
  • Name
    dynein, axonemal, heavy chain 11
  • Synonyms
    avc4, b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, b2b598Clo, Dnahc11, lrd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100864
    NCBI Gene: 13411
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:117841717-118162778 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.25 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8994 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100864
 protein coding gene Chr12:117841717-118162778 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020186
 protein coding gene Chr12:120819999-121166438 (-)
A/J MGP_AJ_G0020142
 protein coding gene Chr12:116362467-116686079 (-)
AKR/J MGP_AKRJ_G0020117
 protein coding gene Chr12:119891117-120226306 (-)
BALB/cJ MGP_BALBcJ_G0020125
 protein coding gene Chr12:116785174-117117152 (-)
C3H/HeJ MGP_C3HHeJ_G0019929
 protein coding gene Chr12:120176945-120525997 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020572
 protein coding gene Chr12:124597982-124948199 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018184
 protein coding gene Chr12:112755212-113067524 (-)
CAST/EiJ MGP_CASTEiJ_G0019469
 protein coding gene Chr12:114035982-114378985 (-)
CBA/J MGP_CBAJ_G0019896
 protein coding gene Chr12:129503948-129873202 (-)
DBA/2J MGP_DBA2J_G0020013
 protein coding gene Chr12:115763120-116085694 (-)
FVB/NJ MGP_FVBNJ_G0019998
 protein coding gene Chr12:114433187-114754449 (-)
LP/J MGP_LPJ_G0020087
 protein coding gene Chr12:120850715-121188743 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020034
 protein coding gene Chr12:132765045-133119899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020601
 protein coding gene Chr12:119059613-119402750 (-)
PWK/PhJ MGP_PWKPhJ_G0019231
 protein coding gene Chr12:110515958-110839969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019036
 protein coding gene Chr12:112021126-112355021 (-)
WSB/EiJ MGP_WSBEiJ_G0019527
 protein coding gene Chr12:120041583-120380728 (-)



Homology
more
  • Human Ortholog
    DNAH11, dynein axonemal heavy chain 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH11, dynein axonemal heavy chain 11
  • Synonyms
    CILD7, DNAHBL, DNAHC11, DNHBL, DPL11
  • Links
    NCBI Gene ID: 8701
    neXtProt AC: NX_Q96DT5
    UniProt: Q96DT5

  • Chr Location
    7p15.3; chr7:21543039-21901839 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Dnah11 mouse models; 2 with human DNAH11 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 8 models
      
IDs
 View 1 model
IDs
 View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 15 alleles in 15 genetic backgrounds
    119 images
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    26
  • cDNA Data
    18
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13411 NCBI Gene Model | MGI Sequence Detail 321062 C57BL/6J ±  kb
    transcript NM_010060 RefSeq | MGI Sequence Detail 14072 ZRU/MplStud  
    polypeptide NP_034190 RefSeq | MGI Sequence Detail 4488 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      E9Q7N9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 8
      cDNA 19
      Primer pair 7
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11512, MGI:4821843, MGI:5311338, MGI:5311353, MGI:5311358, MGI:5437063, MGI:5437717, MGI:96625
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 17
      Diseases 7
      Gene Ontology 14
      Phenotypes 124
    • Earliest
      J:212 Hummel KP, et al., Visceral inversion and associated anomalies in the mouse. J Hered. 1959;50(1):9-13
    • Latest
      J:325522 Urbano-Gamez JD, et al., Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model. Mol Brain. 2021 May 25;14(1):84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory