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Tbrg1 Gene Detail
Summary
  • Symbol
    Tbrg1
  • Name
    transforming growth factor beta regulated gene 1
  • Synonyms
    TB-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100877
    NCBI Gene: 21376
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37560478-37568608 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100877
 protein coding gene Chr9:37560059-37568608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034571
 protein coding gene Chr9:35652780-35663605 (-)
A/J MGP_AJ_G0034550
 protein coding gene Chr9:34696263-34704449 (-)
AKR/J MGP_AKRJ_G0034477
 protein coding gene Chr9:35457194-35467033 (-)
BALB/cJ MGP_BALBcJ_G0034541
 protein coding gene Chr9:34532078-34540366 (-)
C3H/HeJ MGP_C3HHeJ_G0034254
 protein coding gene Chr9:35892431-35901317 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035063
 protein coding gene Chr9:36787983-36796052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031989
 protein coding gene Chr9:33798686-33806646 (-)
CAST/EiJ MGP_CASTEiJ_G0033575
 protein coding gene Chr9:35586274-35596041 (-)
CBA/J MGP_CBAJ_G0034227
 protein coding gene Chr9:38054858-38065314 (-)
DBA/2J MGP_DBA2J_G0034385
 protein coding gene Chr9:34742449-34751084 (-)
FVB/NJ MGP_FVBNJ_G0034326
 protein coding gene Chr9:33998761-34006912 (-)
LP/J MGP_LPJ_G0034470
 protein coding gene Chr9:35827933-35836043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034372
 protein coding gene Chr9:39666359-39675218 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035082
 protein coding gene Chr9:35394737-35404135 (-)
PWK/PhJ MGP_PWKPhJ_G0033281
 protein coding gene Chr9:34616907-34647510 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033115
 protein coding gene Chr9:35596771-35607964 (-)
WSB/EiJ MGP_WSBEiJ_G0033691
 protein coding gene Chr9:35212643-35221756 (-)



Homology
more
  • Human Ortholog
    TBRG1, transforming growth factor beta regulator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBRG1, transforming growth factor beta regulator 1
  • Synonyms
    NIAM, TB-5
  • Links
    NCBI Gene ID: 84897
    neXtProt AC: NX_Q3YBR2
    UniProt: Q3YBR2

  • Chr Location
    11q24.2; chr11:124622836-124635926 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit increased embryonic survival and increased tumor incidence including B cell lymphoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    22
  • cDNA Data
    187
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21376 NCBI Gene Model | MGI Sequence Detail 8131 C57BL/6J ±  kb
    transcript NM_025289 RefSeq | MGI Sequence Detail 1583 C57BL/6  
    polypeptide Q3UB74 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 187
      cDNA 187

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142923, MGI:2142935
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:26127 Babalola GO, et al., Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Mol Reprod Dev. 1995 Jun;41(2):133-9
    • Latest
      J:253581 Pardo M, et al., Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells. Sci Rep. 2017 Aug 15;7(1):8157
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory