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Selenow Gene Detail
Summary
  • Symbol
    Selenow
  • Name
    selenoprotein W
  • Synonyms
    Sepw1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100878
    NCBI Gene: 20364
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15651133-15656296 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.62 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100878
 protein coding gene Chr7:15651133-15656327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031693
 protein coding gene Chr7:13560386-13565420 (-)
A/J MGP_AJ_G0031665
 protein coding gene Chr7:13375703-13380734 (-)
AKR/J MGP_AKRJ_G0031590
 protein coding gene Chr7:13666657-13671688 (-)
BALB/cJ MGP_BALBcJ_G0031672
 protein coding gene Chr7:13472794-13477828 (-)
C3H/HeJ MGP_C3HHeJ_G0031394
 protein coding gene Chr7:13843330-13848364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032138
 protein coding gene Chr7:14301903-14306938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029217
 protein coding gene Chr7:14932269-14937284 (-)
CAST/EiJ MGP_CASTEiJ_G0030745
 protein coding gene Chr7:10610572-10615642 (-)
CBA/J MGP_CBAJ_G0031353
 protein coding gene Chr7:14749849-14757619 (-)
DBA/2J MGP_DBA2J_G0031509
 protein coding gene Chr7:13256607-13261747 (-)
FVB/NJ MGP_FVBNJ_G0031465
 protein coding gene Chr7:13145432-13150350 (-)
LP/J MGP_LPJ_G0031594
 protein coding gene Chr7:13828986-13834020 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031500
 protein coding gene Chr7:14736551-14741575 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032167
 protein coding gene Chr7:13444887-13449921 (-)
PWK/PhJ MGP_PWKPhJ_G0030469
 protein coding gene Chr7:10766951-10772205 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030297
 protein coding gene Chr7:8369843-8374869 (-)
WSB/EiJ MGP_WSBEiJ_G0030842
 protein coding gene Chr7:13484502-13489515 (-)



Homology
more
  • Human Ortholog
    SELENOW, selenoprotein W
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELENOW, selenoprotein W
  • Synonyms
    selW, SEPW1
  • Links
    NCBI Gene ID: 6415
    neXtProt AC: NX_P63302
    UniProt: P63302

  • Chr Location
    19q13.33; chr19:47778677-47784686 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced osteoclast formation, increased bone mass and mineral density, increased trabecular bone volume, thickness and spacing, and a slight increase in body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    10
  • cDNA Data
    287
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20364 NCBI Gene Model | MGI Sequence Detail 5164 C57BL/6J ±  kb
    transcript NM_009156 RefSeq | MGI Sequence Detail 722 C57BL/6  
    polypeptide P63300 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 291
      Genomic 3
      cDNA 287
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:41818 Gu QP, et al., Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. Gene. 1997 Jul 9;193(2):187-96
    • Latest
      J:352236 Ren B, et al., Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model. Commun Biol. 2024 Jul 17;7(1):872
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory