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Elavl2 Gene Detail
Summary
  • Symbol
    Elavl2
  • Name
    ELAV like RNA binding protein 1
  • Synonyms
    Hub, mel-N1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100887
    NCBI Gene: 15569
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:91139000-91289022 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3534 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100887
 protein coding gene Chr4:91099770-91289022 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028445
 protein coding gene Chr4:91233018-91388668 (-)
A/J MGP_AJ_G0028407
 protein coding gene Chr4:88035829-88187027 (-)
AKR/J MGP_AKRJ_G0028355
 protein coding gene Chr4:90187285-90341453 (-)
BALB/cJ MGP_BALBcJ_G0028426
 protein coding gene Chr4:88306626-88460925 (-)
C3H/HeJ MGP_C3HHeJ_G0028138
 protein coding gene Chr4:90988486-91149124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028865
 protein coding gene Chr4:94708956-94865206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026159
 protein coding gene Chr4:83790292-83940352 (-)
CAST/EiJ MGP_CASTEiJ_G0027579
 protein coding gene Chr4:88832190-88987787 (-)
CBA/J MGP_CBAJ_G0028108
 protein coding gene Chr4:97598628-97764331 (-)
DBA/2J MGP_DBA2J_G0028258
 protein coding gene Chr4:87763246-87920050 (-)
FVB/NJ MGP_FVBNJ_G0028225
 protein coding gene Chr4:86696369-86845722 (-)
LP/J MGP_LPJ_G0028358
 protein coding gene Chr4:91533827-91690770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028254
 protein coding gene Chr4:102799064-102954588 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028903
 protein coding gene Chr4:90375239-90538924 (-)
PWK/PhJ MGP_PWKPhJ_G0027303
 protein coding gene Chr4:86041441-86191114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027124
 protein coding gene Chr4:87847071-88002307 (-)
WSB/EiJ MGP_WSBEiJ_G0027657
 protein coding gene Chr4:90578689-90731975 (-)



Homology
more
  • Human Ortholog
    ELAVL2, ELAV like RNA binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELAVL2, ELAV like RNA binding protein 2
  • Synonyms
    HEL-N1, HELN1, HUB
  • Links
    NCBI Gene ID: 1993
    neXtProt AC: NX_Q12926
    UniProt: Q12926

  • Chr Location
    9p21.3; chr9:23690104-23850601 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit incomplete postnatal lethality, postnatal growth retardation, and female infertility associated with loss of oocytes shortly after birth and defective primordial follicle formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1185
  • Tissues
    184
  • cDNA Data
    19
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008489 Ensembl Gene Model | MGI Sequence Detail 150023 C57BL/6J ±  kb
    transcript ENSMUST00000107116 Ensembl | MGI Sequence Detail 1282 Not Applicable  
    polypeptide ENSMUSP00000102733 Ensembl | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 20
      Primer pair 5

      Microarray probesets 8
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 39
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:8170 Saxton AM, et al., New mutation causing jaundice in mice. J Hered. 1985 Nov-Dec;76(6):441-6
    • Latest
      J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory