About   Help   FAQ
Slc18a3 Gene Detail
Summary
  • Symbol
    Slc18a3
  • Name
    solute carrier family 18 (vesicular monoamine), member 3
  • Synonyms
    VAChT, VAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101061
    NCBI Gene: 20508
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32184395-32186807 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101061
 protein coding gene Chr14:32184394-32186807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021146
 protein coding gene Chr14:25712288-25714701 (-)
A/J MGP_AJ_G0021094
 protein coding gene Chr14:24728564-24730976 (-)
AKR/J MGP_AKRJ_G0021071
 protein coding gene Chr14:25880987-25883399 (-)
BALB/cJ MGP_BALBcJ_G0021098
 protein coding gene Chr14:24910059-24912471 (-)
C3H/HeJ MGP_C3HHeJ_G0020881
 protein coding gene Chr14:25757396-25759808 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021530
 protein coding gene Chr14:26732713-26735125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019092
 protein coding gene Chr14:24797492-24799904 (-)
CAST/EiJ MGP_CASTEiJ_G0020406
 protein coding gene Chr14:25550880-25553295 (-)
CBA/J MGP_CBAJ_G0020848
 protein coding gene Chr14:27736841-27739253 (-)
DBA/2J MGP_DBA2J_G0020970
 protein coding gene Chr14:24758290-24760702 (-)
FVB/NJ MGP_FVBNJ_G0020954
 protein coding gene Chr14:24721061-24723473 (-)
LP/J MGP_LPJ_G0021039
 protein coding gene Chr14:26032543-26034956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020980
 protein coding gene Chr14:26943048-26945460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021563
 protein coding gene Chr14:25671059-25673471 (-)
PWK/PhJ MGP_PWKPhJ_G0020154
 protein coding gene Chr14:24235120-24237530 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019978
 protein coding gene Chr14:25280761-25283166 (-)
WSB/EiJ MGP_WSBEiJ_G0020461
 protein coding gene Chr14:25728002-25730415 (-)



Homology
more
  • Human Ortholog
    SLC18A3, solute carrier family 18 member A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18A3, solute carrier family 18 member A3
  • Synonyms
    CMS21, VACHT
  • Links
    NCBI Gene ID: 6572
    neXtProt AC: NX_Q16572
    UniProt: Q16572

  • Chr Location
    10q11.23; chr10:49610310-49612720 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC18A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 2 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased acetylcholine release, grip strength, coordination, exercise endurance, and social recognition memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    959
  • Tissues
    107
  • cDNA Data
    8
  • Literature Summary
    108
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000100241 Ensembl Gene Model | MGI Sequence Detail 2413 C57BL/6J ±  kb
    transcript ENSMUST00000191501 Ensembl | MGI Sequence Detail 2413 Not Applicable  
    polypeptide ENSMUSP00000139829 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 9
      Primer pair 2
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 108
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:263491 Carroll PT, The effect of the acetylcholine transport blocker 2-(4-phenylpiperidino) cyclohexanol (AH5183) on the subcellular storage and release of acetylcholine in mouse brain. Brain Res. 1985 Dec 9;358(1-2):200-9
    • Latest
      J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory