H3f3b MGI Mouse Gene Detail - MGI:1101768

Symbol

H3f3b
Name

H3.3 histone B
Synonyms

9430068D06Rik, H3-3b, H3.3B

Feature Type

protein coding gene
IDs

MGI:1101768
NCBI Gene: 15081
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:115912738-115918788 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.91 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1101768	protein coding gene	Chr11:115912738-115921313 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019410	protein coding gene	Chr11:120102778-120111377 (-)
A/J	MGP_AJ_G0019379	protein coding gene	Chr11:114856180-114857332 (-)
AKR/J	MGP_AKRJ_G0019349	protein coding gene	Chr11:118283444-118290130 (-)
BALB/cJ	MGP_BALBcJ_G0019353	protein coding gene	Chr11:115266897-115275497 (-)
C3H/HeJ	MGP_C3HHeJ_G0019159	protein coding gene	Chr11:118632161-118638078 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019803	protein coding gene	Chr11:123768233-123787480 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017426	protein coding gene	Chr11:111874008-111879695 (-)
CAST/EiJ	MGP_CASTEiJ_G0018714	protein coding gene	Chr11:119979379-119986416 (-)
CBA/J	MGP_CBAJ_G0019131	protein coding gene	Chr11:128669384-128676862 (-)
DBA/2J	MGP_DBA2J_G0019242	protein coding gene	Chr11:114273348-114279615 (-)
FVB/NJ	MGP_FVBNJ_G0019234	protein coding gene	Chr11:113784420-113785384 (-)
LP/J	MGP_LPJ_G0019312	protein coding gene	Chr11:120484573-120491098 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019267	protein coding gene	Chr11:127768732-127775364 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019841	protein coding gene	Chr11:118938283-118944284 (-)
PWK/PhJ	MGP_PWKPhJ_G0018478	protein coding gene	Chr11:115606241-115612880 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018271	protein coding gene	Chr11:118691925-118699598 (-)
WSB/EiJ	MGP_WSBEiJ_G0018766	protein coding gene	Chr11:118897320-118904220 (-)

Human Ortholog

H3-3A, H3.3 histone A

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H3-3A, H3.3 histone A
Synonyms

BRYLIB1, H3.3A, H3-3B, H3F3, H3F3A
Links

HGNC:4764

NCBI Gene ID: 3020

neXtProt AC: NX_P84243

UniProt: P84243
Chr Location

1q42.12; chr1:226061831-226072019 (+) GRCh38

Human Ortholog

H3-3B, H3.3 histone B
Synonyms

BRYLIB2, H3-3A, H3.3B, H3F3B
Links

HGNC:4765

NCBI Gene ID: 3021

neXtProt AC: NX_P84243

UniProt: P84243
Chr Location

17q25.1; chr17:75776434-75785893 (-) GRCh38

MGI Vertebrate Homology

H3f3b stringent orthology
2 human;1 mouse;2 rat;5 zebrafish
HCOP

vertebrate homology predictions: H3-3A, H3-3B
Gene Tree

H3f3b

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Phenotype Summary

15 phenotypes from 5 alleles in 5 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

3
Gene trapped

11
Targeted

10
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis.

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

57
cDNA Data

59
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase h3-3b

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All Sequences

90
RefSeq

4
CCDS

CCDS36377.1

Ensembl

ENSMUSG00000016559 (Evidence)
NCBI Gene

15081

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016559	Ensembl Gene Model \| MGI Sequence Detail	6051	C57BL/6J	± kb
transcript	ENSMUST00000016703	Ensembl \| MGI Sequence Detail	1993	Not Applicable
polypeptide	ENSMUSP00000016703	Ensembl \| MGI Sequence Detail	136	Not Applicable

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All nucleic 63

cDNA 60

Primer pair 3

Microarray probesets 5

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MGI:1926214

Summaries

All 60

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 19
Earliest

J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for H3f3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111820	Chr11:115918787-115918804 (-)	-8 bp
Tssr111819	Chr11:115918760-115918771 (-)	22 bp
Tssr111818	Chr11:115918675-115918684 (-)	108 bp
Tssr111817	Chr11:115918217-115918227 (-)	566 bp
Tssr111816	Chr11:115915315-115915337 (-)	3,462 bp
Tssr111815	Chr11:115914911-115914940 (-)	3,862 bp
Tssr3736	Chr11:115914884-115914908 (-)	3,892 bp
Tssr111814	Chr11:115914790-115914803 (-)	3,991 bp
Tssr111813	Chr11:115913662-115913676 (-)	5,119 bp
Tssr111812	Chr11:115913474-115913503 (-)	5,299 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24