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Hdgfl2 Gene Detail
Summary
  • Symbol
    Hdgfl2
  • Name
    HDGF like 2
  • Synonyms
    Hdgfrp2, HRP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194492
    NCBI Gene: 15193
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56386661-56407605 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.15 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194492
 protein coding gene Chr17:56386634-56407607 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023911
 protein coding gene Chr17:57718575-57744551 (+)
A/J MGP_AJ_G0023871
 protein coding gene Chr17:56156361-56177912 (+)
AKR/J MGP_AKRJ_G0023840
 protein coding gene Chr17:56839628-56861713 (+)
BALB/cJ MGP_BALBcJ_G0023872
 protein coding gene Chr17:55991317-56015233 (+)
C3H/HeJ MGP_C3HHeJ_G0023635
 protein coding gene Chr17:57544938-57570008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024316
 protein coding gene Chr17:60008909-60030992 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021763
 protein coding gene Chr17:52669605-52686548 (+)
CAST/EiJ MGP_CASTEiJ_G0023118
 protein coding gene Chr17:57864060-57886721 (+)
CBA/J MGP_CBAJ_G0023612
 protein coding gene Chr17:62299491-62324900 (+)
DBA/2J MGP_DBA2J_G0023740
 protein coding gene Chr17:54885823-54907007 (+)
FVB/NJ MGP_FVBNJ_G0023706
 protein coding gene Chr17:54405680-54427496 (+)
LP/J MGP_LPJ_G0023820
 protein coding gene Chr17:58428673-58452956 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023733
 protein coding gene Chr17:61858972-61882882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024361
 protein coding gene Chr17:57213893-57238196 (+)
PWK/PhJ MGP_PWKPhJ_G0022863
 protein coding gene Chr17:54229227-54251229 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022675
 protein coding gene Chr17:53984775-54008517 (+)
WSB/EiJ MGP_WSBEiJ_G0023182
 protein coding gene Chr17:57832137-57854595 (+)



Homology
more
  • Human Ortholog
    HDGFL2, HDGF like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDGFL2, HDGF like 2
  • Synonyms
    HDGF-2, HDGF2, HDGFRP2, HRP-2, HRP2
  • Links
    NCBI Gene ID: 84717
    neXtProt AC: NX_Q7Z4V5
    UniProt: Q7Z4V5

  • Chr Location
    19p13.3; chr19:4472297-4502208 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit an increased mean serum alkaline phosphatase level compared to controls. Female mutants exhibited a decreased mean skin fibroblast proliferation rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    10
  • cDNA Data
    111
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15193 NCBI Gene Model | MGI Sequence Detail 20945 C57BL/6J ±  kb
    transcript NM_001304784 RefSeq | MGI Sequence Detail 2283 C57BL/6  
    polypeptide Q3UMU9 UniProt | EBI | MGI Sequence Detail 669 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008492 hepatoma-derived growth factor-related protein 2
      (term hierarchy)
    • InterPro Domains
      IPR036218 HIV integrase-binding domain superfamily
      IPR021567 Lens epithelium-derived growth factor, integrase-binding domain
      IPR000313 PWWP domain
      IPR035441 TFIIS/LEDGF domain superfamily
    • GlyGen
      Q3UMU9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5883594
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:42918 Izumoto Y, et al., Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory