Atp2a3 MGI Mouse Gene Detail - MGI:1194503 - ATPase, Ca++ transporting, ubiquitous

Symbol

Atp2a3
Name

ATPase, Ca++ transporting, ubiquitous
Synonyms

Serca3

Feature Type

protein coding gene
IDs

MGI:1194503
NCBI Gene: 53313
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:72851995-72883869 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.00 cM
Mapping Data

2 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194503	protein coding gene	Chr11:72851995-72883870 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018647	protein coding gene	Chr11:73626119-73660287 (+)
A/J	MGP_AJ_G0018615	protein coding gene	Chr11:70862661-70894505 (+)
AKR/J	MGP_AKRJ_G0018584	protein coding gene	Chr11:73019405-73052191 (+)
BALB/cJ	MGP_BALBcJ_G0018587	protein coding gene	Chr11:71164436-71196284 (+)
C3H/HeJ	MGP_C3HHeJ_G0018400	protein coding gene	Chr11:72983259-73016665 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019038	protein coding gene	Chr11:75843642-75880606 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016681	protein coding gene	Chr11:67672425-67705433 (+)
CAST/EiJ	MGP_CASTEiJ_G0017955	protein coding gene	Chr11:73360653-73394017 (+)
CBA/J	MGP_CBAJ_G0018372	protein coding gene	Chr11:79216240-79251634 (+)
DBA/2J	MGP_DBA2J_G0018481	protein coding gene	Chr11:70493554-70525288 (+)
FVB/NJ	MGP_FVBNJ_G0018472	protein coding gene	Chr11:70037050-70069070 (+)
LP/J	MGP_LPJ_G0018552	protein coding gene	Chr11:74122782-74154463 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018495	protein coding gene	Chr11:79743006-79775331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019080	protein coding gene	Chr11:73218615-73250252 (+)
PWK/PhJ	MGP_PWKPhJ_G0017728	protein coding gene	Chr11:71129236-71161427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017518	protein coding gene	Chr11:72927362-72959954 (+)
WSB/EiJ	MGP_WSBEiJ_G0018009	protein coding gene	Chr11:72960722-72992787 (+)

Human Ortholog

ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP2A3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Synonyms

SERCA3
Links

HGNC:813

NCBI Gene ID: 489

neXtProt AC: NX_Q93084

UniProt: Q93084
Chr Location

17p13.2; chr17:3923870-3964464 (-) GRCh38

MGI Vertebrate Homology

Atp2a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP2A3
Gene Tree

Atp2a3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Atp2a3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available

Homozygous mutation of this gene results in reduced endothelial-dependent relaxation in the aorta.

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All GO Annotations

38
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

112
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ATP2A3

Xenbase atp2a3

ZFIN atp2a3

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All Sequences

59
RefSeq

6
UniProt

9
CCDS

CCDS24991.1, CCDS48842.1, CCDS48843.1

Ensembl

ENSMUSG00000020788 (Evidence)
NCBI Gene

53313

			Length	Strain/Species	Flank
genomic	53313	NCBI Gene Model \| MGI Sequence Detail	31875	C57BL/6J	± kb
transcript	NM_001163337	RefSeq \| MGI Sequence Detail	4606	C57BL/6
polypeptide	Q64518	UniProt \| EBI \| MGI Sequence Detail	999	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000004444 sarcoplasmic/endoplasmic reticulum calcium ATPase 3

(term hierarchy)
EC

7.2.2.10
InterPro Domains

IPR006068 Cation-transporting P-type ATPase, C-terminal

IPR004014 Cation-transporting P-type ATPase, N-terminal

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR018303 P-type ATPase, phosphorylation site

IPR005782 P-type ATPase, subfamily IIA, SERCA-type

IPR023298 P-type ATPase, transmembrane domain superfamily
GlyGen

Q64518 1 site, 1 O-linked glycan (1 site)

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All nucleic 114

Genomic 1

cDNA 112

Primer pair 1

Microarray probesets 5

Summaries

All 61

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:294971 Fecher-Trost C, et al., Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710

TSS for Atp2a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102861	Chr11:72851114-72851121 (+)	-877 bp
Tssr102862	Chr11:72851989-72852005 (+)	2 bp
Tssr102863	Chr11:72852006-72852054 (+)	35 bp
Tssr102864	Chr11:72882793-72882805 (+)	30,804 bp
Tssr102865	Chr11:72883464-72883475 (+)	31,475 bp
Tssr102866	Chr11:72883507-72883520 (+)	31,519 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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