Gpc5 MGI Mouse Gene Detail - MGI:1194894

Symbol

Gpc5
Name

glypican 5
Synonyms

A230034F01Rik

Feature Type

protein coding gene
IDs

MGI:1194894
NCBI Gene: 103978
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:115329647-116762591 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 59.43 cM, cytoband E4
Mapping Data

5 experiments

SNPs within 2kb

43907 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194894	protein coding gene	Chr14:115329640-116762604 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021644	protein coding gene	Chr14:112549865-114040770 (+)
A/J	MGP_AJ_G0021603	protein coding gene	Chr14:108300147-109702958 (+)
AKR/J	MGP_AKRJ_G0021579	protein coding gene	Chr14:111831423-113283646 (+)
BALB/cJ	MGP_BALBcJ_G0021609	protein coding gene	Chr14:108815586-110232601 (+)
C3H/HeJ	MGP_C3HHeJ_G0021387	protein coding gene	Chr14:111656700-113127648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022049	protein coding gene	Chr14:116881106-118455037 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019588	protein coding gene	Chr14:104467326-105820784 (+)
CAST/EiJ	MGP_CASTEiJ_G0020903	protein coding gene	Chr14:109434925-110948393 (+)
CBA/J	MGP_CBAJ_G0021355	protein coding gene	Chr14:121418844-123058554 (+)
DBA/2J	MGP_DBA2J_G0021478	protein coding gene	Chr14:108216969-109624295 (+)
FVB/NJ	MGP_FVBNJ_G0021456	protein coding gene	Chr14:106562747-107958966 (+)
LP/J	MGP_LPJ_G0021546	protein coding gene	Chr14:113575441-115061091 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021483	protein coding gene	Chr14:126298608-128093208 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022072	protein coding gene	Chr14:111263605-112707211 (+)
PWK/PhJ	MGP_PWKPhJ_G0020647	protein coding gene	Chr14:105163805-106592765 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020485	protein coding gene	Chr14:107399961-108915039 (+)
WSB/EiJ	MGP_WSBEiJ_G0020958	protein coding gene	Chr14:112004909-113504366 (+)

Human Ortholog

GPC5, glypican 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPC5, glypican 5
Links

HGNC:4453

NCBI Gene ID: 2262

neXtProt AC: NX_P78333

UniProt: P78333
Chr Location

13q31.3; chr13:91398621-92873682 (+) GRCh38

MGI Vertebrate Homology

Gpc5 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: GPC5
Gene Tree

Gpc5

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Phenotype Summary

17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

3 involving Gpc5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

21
cDNA Data

10
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpc5

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All Sequences

56
RefSeq

16
UniProt

5
CCDS

CCDS27329.1

Ensembl

ENSMUSG00000022112 (Evidence)
NCBI Gene

103978

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022112	Ensembl Gene Model \| MGI Sequence Detail	1432945	C57BL/6J	± kb
transcript	ENSMUST00000176912	Ensembl \| MGI Sequence Detail	2837	Not Applicable
polypeptide	ENSMUSP00000135085	Ensembl \| MGI Sequence Detail	645	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008167 glypican-5

(term hierarchy)
InterPro Domains

IPR001863 Glypican

IPR019803 Glypican, conserved site
GlyGen

Q8CAL5 8 sites, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 2

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MGI:2442523

Summaries

All 55

Developmental Gene Expression 13

Gene Ontology 5

Phenotypes 17
Earliest

J:45283 Saunders S, et al., Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997 Oct 1;190(1):78-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127132	Chr14:115329676-115329710 (+)	46 bp
Tssr127133	Chr14:115329721-115329728 (+)	78 bp
Tssr127134	Chr14:115438998-115439005 (+)	109,355 bp
Tssr127135	Chr14:115860477-115860482 (+)	530,833 bp
Tssr127136	Chr14:116106176-116106179 (+)	776,531 bp
Tssr127137	Chr14:116180007-116180010 (+)	850,362 bp
Tssr127138	Chr14:116232355-116232359 (+)	902,710 bp
Tssr127139	Chr14:116632407-116632408 (+)	1,302,761 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24