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Dsc3 Gene Detail
Summary
  • Symbol
    Dsc3
  • Name
    desmocollin 3
  • Synonyms
    5430426I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194993
    NCBI Gene: 13507
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20093987-20135408 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1499 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194993
 protein coding gene Chr18:20093987-20135465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024175
 protein coding gene Chr18:17454463-17495283 (-)
A/J MGP_AJ_G0024138
 protein coding gene Chr18:16978220-17019954 (-)
AKR/J MGP_AKRJ_G0024105
 protein coding gene Chr18:17516526-17558213 (-)
BALB/cJ MGP_BALBcJ_G0024137
 protein coding gene Chr18:17013576-17055830 (-)
C3H/HeJ MGP_C3HHeJ_G0023905
 protein coding gene Chr18:17433012-17475422 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024581
 protein coding gene Chr18:18279074-18321739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022021
 protein coding gene Chr18:16163151-16207974 (-)
CAST/EiJ MGP_CASTEiJ_G0023381
 protein coding gene Chr18:17276916-17328174 (-)
CBA/J MGP_CBAJ_G0023875
 protein coding gene Chr18:18750319-18792190 (-)
DBA/2J MGP_DBA2J_G0024005
 protein coding gene Chr18:16748801-16790727 (-)
FVB/NJ MGP_FVBNJ_G0023970
 protein coding gene Chr18:16521831-16567377 (-)
LP/J MGP_LPJ_G0024088
 protein coding gene Chr18:17576679-17617671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023999
 protein coding gene Chr18:19596509-19655746 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024628
 protein coding gene Chr18:17257033-17301368 (-)
PWK/PhJ MGP_PWKPhJ_G0023126
 protein coding gene Chr18:16836051-16878619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022935
 protein coding gene Chr18:17536195-17580183 (-)
WSB/EiJ MGP_WSBEiJ_G0023446
 protein coding gene Chr18:17208183-17250817 (-)



Homology
more
  • Human Ortholog
    DSC3, desmocollin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSC3, desmocollin 3
  • Synonyms
    CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
  • Links
    NCBI Gene ID: 1825
    neXtProt AC: NX_Q14574
    UniProt: Q14574

  • Chr Location
    18q12.1; chr18:30989365-31042815 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before implantation. Heterozygous mice do not display any gross abnormalities and have normal epidermal development and keratinocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    104
  • cDNA Data
    26
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059898 Ensembl Gene Model | MGI Sequence Detail 41422 C57BL/6J ±  kb
    transcript ENSMUST00000225110 Ensembl | MGI Sequence Detail 3123 Not Applicable  
    polypeptide ENSMUSP00000153261 Ensembl | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 28
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918578
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 18
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:18927 Buxton RS, et al., Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994 Jun;21(3):510-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory