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Man2b2 Gene Detail
Summary
  • Symbol
    Man2b2
  • Name
    mannosidase 2, alpha B2
  • Synonyms
    135 kDa alpha-D-mannosidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195262
    NCBI Gene: 17160
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36964265-36987997 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.26 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    742 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195262
 protein coding gene Chr5:36963913-36987997 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029495
 protein coding gene Chr5:35137798-35161532 (-)
A/J MGP_AJ_G0029461
 protein coding gene Chr5:33987923-34011656 (-)
AKR/J MGP_AKRJ_G0029411
 protein coding gene Chr5:35268115-35291848 (-)
BALB/cJ MGP_BALBcJ_G0029472
 protein coding gene Chr5:34486453-34510591 (-)
C3H/HeJ MGP_C3HHeJ_G0029195
 protein coding gene Chr5:35274505-35298238 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029926
 protein coding gene Chr5:37058840-37082572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027164
 protein coding gene Chr5:31710185-31734152 (-)
CAST/EiJ MGP_CASTEiJ_G0028603
 protein coding gene Chr5:34403265-34441319 (-)
CBA/J MGP_CBAJ_G0029162
 protein coding gene Chr5:37960246-37986026 (-)
DBA/2J MGP_DBA2J_G0029309
 protein coding gene Chr5:34114183-34137936 (-)
FVB/NJ MGP_FVBNJ_G0029268
 protein coding gene Chr5:33591825-33616466 (-)
LP/J MGP_LPJ_G0029395
 protein coding gene Chr5:35592473-35617607 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029298
 protein coding gene Chr5:38698571-38723250 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029959
 protein coding gene Chr5:34760124-34783648 (-)
PWK/PhJ MGP_PWKPhJ_G0028327
 protein coding gene Chr5:33295990-33319623 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028160
 protein coding gene Chr5:34221301-34260519 (-)
WSB/EiJ MGP_WSBEiJ_G0028684
 protein coding gene Chr5:34845373-34869047 (-)



Homology
more
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
  • Synonyms
    EpMAN
  • Links
    NCBI Gene ID: 23324
    neXtProt AC: NX_Q9Y2E5
    UniProt: Q9Y2E5

  • Chr Location
    4p16.1; chr4:6575189-6623362 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    99
  • cDNA Data
    43
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029119 Ensembl Gene Model | MGI Sequence Detail 23733 C57BL/6J ±  kb
    transcript ENSMUST00000031002 Ensembl | MGI Sequence Detail 3330 Not Applicable  
    polypeptide ENSMUSP00000031002 Ensembl | MGI Sequence Detail 1018 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000010108 epididymis-specific alpha-mannosidase
      (term hierarchy)
    • EC
      3.2.1.-, 3.2.1.24
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR013780 Glycosyl hydrolase, all-beta
      IPR050843 Glycosyl Hydrolase Family 38
      IPR011682 Glycosyl hydrolase family 38, C-terminal
    • GlyGen
      O54782 10 sites
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory