Rdh1 MGI Mouse Gene Detail - MGI:1195275 - retinol dehydrogenase 1 (all trans)

Symbol

Rdh1
Name

retinol dehydrogenase 1 (all trans)

Feature Type

protein coding gene
IDs

MGI:1195275
NCBI Gene: 107605
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:127595595-127604168 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 75.21 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

310 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195275	protein coding gene	Chr10:127595590-127604168 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017835	protein coding gene	Chr10:131391491-131403468 (+)
A/J	MGP_AJ_G0017810	protein coding gene	Chr10:126132933-126143780 (+)
AKR/J	MGP_AKRJ_G0017773	protein coding gene	Chr10:129851649-129865460 (+)
BALB/cJ	MGP_BALBcJ_G0017774	protein coding gene	Chr10:126533327-126542104 (+)
C3H/HeJ	MGP_C3HHeJ_G0017598	protein coding gene	Chr10:130010088-130018121 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018229	protein coding gene	Chr10:135838529-135848963 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015909	protein coding gene	Chr10:120114091-120119657 (+)
CAST/EiJ	MGP_CASTEiJ_G0017158	protein coding gene	Chr10:130679039-130689665 (+)
CBA/J	MGP_CBAJ_G0017567	protein coding gene	Chr10:141327378-141335950 (+)
DBA/2J	MGP_DBA2J_G0017673	protein coding gene	Chr10:125207119-125215618 (+)
FVB/NJ	MGP_FVBNJ_G0017668	protein coding gene	Chr10:124152095-124162087 (+)
LP/J	MGP_LPJ_G0017747	protein coding gene	Chr10:131966223-131976510 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017696	protein coding gene	Chr10:143997314-144006182 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018269	protein coding gene	Chr10:129932502-129941902 (+)
PWK/PhJ	MGP_PWKPhJ_G0016943	protein coding gene	Chr10:125414989-125423736 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016735	protein coding gene	Chr10:128954933-128964382 (+)
WSB/EiJ	no annotation

Human Ortholog

RDH16, retinol dehydrogenase 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RDH16, retinol dehydrogenase 16
Synonyms

hRDH-E, RODH-4, RODH4, SDR9C8
Links

HGNC:29674

NCBI Gene ID: 8608

neXtProt AC: NX_O75452

UniProt: O75452
Chr Location

12q13.3; chr12:56951431-56959374 (-) GRCh38

MGI Vertebrate Homology

Rdh1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RDH16
Gene Tree

Rdh1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased body weight, adipose tissue, and retinol levels.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

29
cDNA Data

7
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

4
UniProt

2
CCDS

CCDS24250.1

Ensembl

ENSMUSG00000089789 (Evidence)
NCBI Gene

107605

			Length	Strain/Species	Flank
genomic	107605	NCBI Gene Model \| MGI Sequence Detail	8574	C57BL/6J	± kb
transcript	NM_080436	RefSeq \| MGI Sequence Detail	3890	ZRU/MplStud
polypeptide	NP_536684	RefSeq \| MGI Sequence Detail	317	ZRU/MplStud

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UniProt

2 Sequences
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 10

cDNA 7

Primer pair 2

Other 1

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 2
Earliest

J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
Latest

J:277757 Krois CR, et al., RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Cell Mol Life Sci. 2019 Jun;76(12):2425-2447

TSS for Rdh1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96255	Chr10:127595603-127595615 (+)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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