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Zbtb14 Gene Detail
Summary
  • Symbol
    Zbtb14
  • Name
    zinc finger and BTB domain containing 14
  • Synonyms
    b2b1982Clo, ZF5, Zfp161
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195345
    NCBI Gene: 22666
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:69690170-69697747 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 40.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195345
 protein coding gene Chr17:69690045-69698194 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023997
 protein coding gene Chr17:71713296-71720096 (+)
A/J MGP_AJ_G0023955
 protein coding gene Chr17:69549534-69556558 (+)
AKR/J MGP_AKRJ_G0023924
 protein coding gene Chr17:70532068-70539189 (+)
BALB/cJ MGP_BALBcJ_G0023956
 protein coding gene Chr17:69486193-69493619 (+)
C3H/HeJ MGP_C3HHeJ_G0023720
 protein coding gene Chr17:71454331-71461724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024402
 protein coding gene Chr17:74310457-74319890 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021848
 protein coding gene Chr17:65433068-65440811 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0023824
 protein coding gene Chr17:68245582-68255563 (+)
FVB/NJ MGP_FVBNJ_G0023790
 protein coding gene Chr17:67736471-67743381 (+)
LP/J MGP_LPJ_G0023906
 protein coding gene Chr17:72468149-72476481 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023818
 protein coding gene Chr17:77346936-77350976 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024446
 protein coding gene Chr17:71030801-71037133 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023268
 protein coding gene Chr17:71780550-71789668 (+)



Homology
more
  • Human Ortholog
    ZBTB14, zinc finger and BTB domain containing 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB14, zinc finger and BTB domain containing 14
  • Synonyms
    ZF5, ZFP-161, ZFP161, ZFP-5, ZNF478
  • Links
    NCBI Gene ID: 7541
    neXtProt AC: NX_O43829
    UniProt: O43829

  • Chr Location
    18p11.31; chr18:5289019-5297053 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation show exencephaly, cardiac defects including valve abnormalities, double outlet right ventricle, perimembranous ventricular septal defect, and atrioventricular septal defect, and renal anomalies such as duplex kidney, hydronephrosis, and kidney cysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    25
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22666 NCBI Gene Model | MGI Sequence Detail 7578 C57BL/6J ±  kb
    transcript NM_009547 RefSeq | MGI Sequence Detail 3947 ZRU/MplStud  
    polypeptide Q08376 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 2
      cDNA 47
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:5476167
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:25666 Numoto M, et al., Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins. Nucleic Acids Res. 1993 Aug 11;21(16):3767-75
    • Latest
      J:308922 Medeiros de Araujo JA, et al., ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development. 2021 Aug 15;148(16):dev196642
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory