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Abce1 Gene Detail
Summary
  • Symbol
    Abce1
  • Name
    ATP-binding cassette, sub-family E member 1
  • Synonyms
    Oabp, Rnaseli, RNS4l (Eye)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195458
    NCBI Gene: 24015
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:80410091-80438369 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 37.77 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    648 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195458
 protein coding gene Chr8:80410071-80438369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033814
 protein coding gene Chr8:80366157-80401112 (-)
A/J MGP_AJ_G0033796
 protein coding gene Chr8:77176404-77205218 (-)
AKR/J MGP_AKRJ_G0033723
 protein coding gene Chr8:79482031-79511669 (-)
BALB/cJ MGP_BALBcJ_G0033790
 protein coding gene Chr8:77290811-77319373 (-)
C3H/HeJ MGP_C3HHeJ_G0033499
 protein coding gene Chr8:80109256-80145344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034310
 protein coding gene Chr8:83453183-83483240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031251
 protein coding gene Chr8:71241976-71266618 (-)
CAST/EiJ MGP_CASTEiJ_G0032830
 protein coding gene Chr8:79444983-79480219 (-)
CBA/J MGP_CBAJ_G0033478
 protein coding gene Chr8:86390524-86418651 (-)
DBA/2J MGP_DBA2J_G0033631
 protein coding gene Chr8:76872407-76900777 (-)
FVB/NJ MGP_FVBNJ_G0033576
 protein coding gene Chr8:75841219-75869075 (-)
LP/J MGP_LPJ_G0033721
 protein coding gene Chr8:80444182-80479947 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033619
 protein coding gene Chr8:88948481-88980658 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034327
 protein coding gene Chr8:79504171-79533770 (-)
PWK/PhJ MGP_PWKPhJ_G0032533
 protein coding gene Chr8:76144110-76173171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032371
 protein coding gene Chr8:78314907-78343725 (-)
WSB/EiJ MGP_WSBEiJ_G0032943
 protein coding gene Chr8:79834081-79865093 (-)



Homology
more
  • Human Ortholog
    ABCE1, ATP binding cassette subfamily E member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCE1, ATP binding cassette subfamily E member 1
  • Synonyms
    ABC38, OABP, RLI, RLI1, RNASEL1, RNASELI, RNS4I
  • Links
    NCBI Gene ID: 6059
    neXtProt AC: NX_P61221
    UniProt: P61221

  • Chr Location
    4q31.21; chr4:145098288-145129524 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ABCE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    13
  • cDNA Data
    284
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058355 Ensembl Gene Model | MGI Sequence Detail 28279 C57BL/6J ±  kb
    transcript ENSMUST00000080536 Ensembl | MGI Sequence Detail 3793 Not Applicable  
    polypeptide ENSMUSP00000079379 Ensembl | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003568 ATP-binding cassette sub-family E member 1
      (term hierarchy)
    • EC
      3.6.5.-
    • InterPro Domains
      IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
      IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
      IPR003593 AAA+ ATPase domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR013283 RLI1
      IPR034348 RLI, domain 1
      IPR007209 RNase L inhibitor RLI-like, possible metal-binding domain
    • GlyGen
      P61222 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 286
      cDNA 285
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139480
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:41448 Semsei I, et al., Expression of mRNAs of pancreatic and L type RNase inhibitors as a function of age in different tissues of SAMP8 and BDF1 mice. Mech Ageing Dev. 1997 Sep;97(3):249-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory