Pira2 Gene Detail

Summary

• Symbol
  Pira2
• Name
  paired-Ig-like receptor A2
• Synonyms
  6M23

• Feature Type
  protein coding gene
• IDs
  MGI:1195970
  NCBI Gene: 18725
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr7:3839811-3848050 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 2.21 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  53 from dbSNP Build 142
• Strain Annotations
  12

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195970	protein coding gene	Chr7:3839807-3848102 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031534	protein coding gene	Chr7:813149-826413 (-)
A/J	MGP_AJ_G0031507	protein coding gene	Chr7:651375-660572 (-)
AKR/J	MGP_AKRJ_G0031444	protein coding gene	Chr7:1236269-1280679 (+)
BALB/cJ	MGP_BALBcJ_G0031517	protein coding gene	Chr7:638360-649329 (-)
C3H/HeJ	MGP_C3HHeJ_G0031238	protein coding gene	Chr7:646941-652066 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031977	protein coding gene	Chr7:692741-765697 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029101	protein coding gene	Chr7:592600-597565 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0031194	protein coding gene	Chr7:778762-826227 (-)
DBA/2J	MGP_DBA2J_G0031355	protein coding gene	Chr7:796122-810252 (-)
FVB/NJ	MGP_FVBNJ_G0031307	protein coding gene	Chr7:769701-780041 (-)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0031343	protein coding gene	Chr7:760985-776504 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  LILRA1, leukocyte immunoglobulin like receptor A1

• Vertebrate Orthologs
  9

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LILRA1, leukocyte immunoglobulin like receptor A1
  
• Synonyms
  CD85I, LIR-6, LIR6
• Links
  HGNC:6602

  NCBI Gene ID: 11024

  neXtProt AC: NX_O75019

  UniProt: O75019

  
  
• Chr Location
  19q13.42; chr19:54593582-54602381 (+)  GRCh38

---

• Human Ortholog
  LILRA2, leukocyte immunoglobulin like receptor A2
  
• Synonyms
  CD85H, ILT1, LIR-7, LIR7
• Links
  HGNC:6603

  NCBI Gene ID: 11027

  neXtProt AC: NX_Q8N149

  UniProt: Q8N149

  
  
• Chr Location
  19q13.42; chr19:54572920-54590287 (+)  GRCh38

---

• Human Ortholog
  LILRA3, leukocyte immunoglobulin like receptor A3
  
• Synonyms
  CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4
• Links
  HGNC:6604

  NCBI Gene ID: 11026

  neXtProt AC: NX_Q8N6C8

  UniProt: Q8N6C8

  
  
• Chr Location
  19q13.4

---

• Human Ortholog
  LILRA4, leukocyte immunoglobulin like receptor A4
  
• Synonyms
  CD85g, ILT7
• Links
  HGNC:15503

  NCBI Gene ID: 23547

  neXtProt AC: NX_P59901

  UniProt: P59901

  
  
• Chr Location
  19q13.42; chr19:54333185-54339162 (-)  GRCh38

---

• Human Ortholog
  LILRA6, leukocyte immunoglobulin like receptor A6
  
• Synonyms
  CD85b, ILT5, ILT-8, ILT8, LILRB3, LILRB6
• Links
  HGNC:15495

  NCBI Gene ID: 79168

  UniProt: Q6PI73

  
  
• Chr Location
  19q13.42; chr19:54236590-54242790 (-)  GRCh38

---

• Human Ortholog
  LILRB3, leukocyte immunoglobulin like receptor B3
  
• Synonyms
  CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIR-B, PIRB
• Links
  HGNC:6607

  NCBI Gene ID: 11025

  neXtProt AC: NX_O75022

  UniProt: O75022

  
  
• Chr Location
  19q13.42; chr19:54216278-54223506 (-)  GRCh38

---

• MGI Vertebrate Homology
  Pira2 stringent orthology
  6 human;1 mouse;3 rat
  
• HCOP
  vertebrate homology predictions: LILRA1, LILRA2, LILRA3, LILRA4, LILRA6, LILRB3
• Gene Tree
  Pira2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  37 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  10
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  43
• RefSeq
  17
• UniProt
  3
• CCDS
  CCDS39731.1

• Ensembl
  ENSMUSG00000089942 (Evidence)
• NCBI Gene
  18725

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000089942	Ensembl Gene Model | MGI Sequence Detail	8240	C57BL/6J
transcript	ENSMUST00000108615	Ensembl | MGI Sequence Detail	3462	Not Applicable
polypeptide	ENSMUSP00000104255	Ensembl | MGI Sequence Detail	680	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR013151 Immunoglobulin
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR050412 Immunoglobulin-like Receptors in Immune Regulation
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2

Molecular
Reagents

• All nucleic 5

  cDNA 4

  Other 1

References

• Summaries
  All 13

  Gene Ontology 2

  Phenotypes 1
• Earliest
  J:44191 Kubagawa H, et al., A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells [see comments]. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5261-6
• Latest
  J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25