Elovl3 Gene Detail

Summary

• Symbol
  Elovl3
• Name
  ELOVL fatty acid elongase 3
• Synonyms
  Cig30, CIN-2, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3

• Feature Type
  protein coding gene
• IDs
  MGI:1195976
  NCBI Gene: 12686
• Alliance
  gene page
• Transcription Start Sites
  1 TSS
• Candidate for QTL
  6 QTL

Location &
Maps

• Sequence Map
  Chr19:46120336-46124133 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 38.75 cM
• Mapping Data
  9 experiments

Strain
Comparison

• SNPs within 2kb
  153 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195976	protein coding gene	Chr19:46120336-46124133 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025200	protein coding gene	Chr19:45803122-45807424 (+)
A/J	MGP_AJ_G0025176	protein coding gene	Chr19:43547621-43551009 (+)
AKR/J	MGP_AKRJ_G0025145	protein coding gene	Chr19:44953831-44957353 (+)
BALB/cJ	MGP_BALBcJ_G0025171	protein coding gene	Chr19:43604330-43607732 (+)
C3H/HeJ	MGP_C3HHeJ_G0024931	protein coding gene	Chr19:45126390-45131552 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025614	protein coding gene	Chr19:46938280-46941688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023028	protein coding gene	Chr19:42787725-42791078 (+)
CAST/EiJ	MGP_CASTEiJ_G0024396	protein coding gene	Chr19:44911205-44914694 (+)
CBA/J	MGP_CBAJ_G0024911	protein coding gene	Chr19:49305383-49309869 (+)
DBA/2J	MGP_DBA2J_G0025043	protein coding gene	Chr19:43367367-43370769 (+)
FVB/NJ	MGP_FVBNJ_G0025004	protein coding gene	Chr19:43144292-43147744 (+)
LP/J	MGP_LPJ_G0025129	protein coding gene	Chr19:45714467-45718561 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025035	protein coding gene	Chr19:48655117-48658644 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025672	protein coding gene	Chr19:45065173-45068735 (+)
PWK/PhJ	MGP_PWKPhJ_G0024145	protein coding gene	Chr19:43303930-43307429 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023949	protein coding gene	Chr19:43723702-43727164 (+)
WSB/EiJ	MGP_WSBEiJ_G0024466	protein coding gene	Chr19:45208571-45211973 (+)

Homology

• Human Ortholog
  ELOVL3, ELOVL fatty acid elongase 3

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ELOVL3, ELOVL fatty acid elongase 3
  
• Synonyms
  CIG-30, CIG30
• Links
  HGNC:18047

  NCBI Gene ID: 83401

  neXtProt AC: NX_Q9HB03

  UniProt: Q9HB03

  
  
• Chr Location
  10q24.32; chr10:102224767-102229589 (+)  GRCh38

---

• MGI Vertebrate Homology
  Elovl3 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: ELOVL3
• Gene Tree
  Elovl3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  22 phenotypes from 2 alleles in 2 genetic backgrounds
  6 images
  12 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (ENU)
  1
• Endonuclease-mediated
  8
• Spontaneous
  1
• Targeted
  2
• Genomic Mutations
  1 involving Elovl3
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous mutants have a sparse coat, hyperplastic pilosebaceous system, and abnormal hair lipid content with high levels of eicosenoic acid. Liver and brown adipose tissue functions are normal.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  23
• GO References
  9

Expression

• Assay Results
  734
• Tissues
  10
• cDNA Data
  33
• Literature Summary
  25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase elovl3

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  4
• UniProt
  3
• CCDS
  CCDS29871.1

• Ensembl
  ENSMUSG00000038754 (Evidence)
• NCBI Gene
  12686

Representative Sequences			Length	Strain/Species
genomic	12686	NCBI Gene Model | MGI Sequence Detail	3798	C57BL/6J
transcript	NM_007703	RefSeq | MGI Sequence Detail	1879	C57BL/6
polypeptide	O35949	UniProt | EBI | MGI Sequence Detail	271	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000007038 very long chain fatty acid elongase 3
  (term hierarchy)
• EC
  2.3.1.199
• InterPro Domains
  IPR002076 ELO family
  IPR030457 ELO family, conserved site
  IPR033679 Elongation of very long chain fatty acids protein 3
• GlyGen
  O35949 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 40

  Genomic 1

  cDNA 34

  Primer pair 5

  
  

  Microarray probesets 4

References

• Summaries
  All 71

  Developmental Gene Expression 25

  Gene Ontology 9

  Phenotypes 12
• Earliest
  J:8101 Jacobsson A, et al., Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem. 1985 Dec 25;260(30):16250-4
• Latest
  J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097

TSS for Elovl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156716	Chr19:46120327-46120343 (+)	-1 bp

Elovl3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Afw8	Chr19, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Bglq13	Chr19, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Iba4	Chr19, 20.99 cM	Chr19:26305715-26305821	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Nobq2	Chr19, 40.53 cM	Chr19:47897880-47897988	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
T2dm2	Chr19, 50.72 cM	Chr19:55376050-55376167	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.
Tanidd1	Chr19, 48.46 cM	Chr19:53752597-53752718	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Iba4 (20 cM) on mouse Chromosome 19 as identified by ExQuest are Aldh1a1 (12 cM), Aldh1a7, Vldlr (20 cM), and Plce1. Vldlr exhibits 15.6-fold increased expression in the liver of Tally Ho compared to C57BL/6 animals. For QTL Afw8 (26 cM), potential candidate genes Pi4k2a, Cpn1, and Elovl3 (47 cM) were identified. For QTLs Nobq2 (47 cM) and Bglq13 (51 cM), potential candidate genes Ins1 (49 cM), Gpam (52 cM), and Acsl5 were identified. For QTLs Tanidd1 (50 cM) and T2dm2 (53 cM), potential candidate genes Gfra1, Pnlip (29 cM), Pnliprp1 (29 cM), and Pnliprp2 were identified. Pnliprp2 exhibits 21.8-fold decreased expression in the pancreas of Tally Ho animals in response to a 4% fat diet.

*cM position of peak correlated region/marker