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Klrk1 Gene Detail
Summary
  • Symbol
    Klrk1
  • Name
    killer cell lectin-like receptor subfamily K, member 1
  • Synonyms
    D6H12S2489E, NKG2-D, Nkg2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196250
    NCBI Gene: 27007
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129587286-129600827 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196250
 protein coding gene Chr6:129587286-129600863 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031354
 protein coding gene Chr6:133284647-133298378 (-)
A/J MGP_AJ_G0031325
 protein coding gene Chr6:128186612-128200207 (-)
AKR/J MGP_AKRJ_G0031253
 protein coding gene Chr6:131685201-131699749 (-)
BALB/cJ MGP_BALBcJ_G0031332
 protein coding gene Chr6:127833528-127849396 (-)
C3H/HeJ MGP_C3HHeJ_G0031056
 protein coding gene Chr6:131883196-131897305 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031791
 protein coding gene Chr6:136782712-136799192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028937
 protein coding gene Chr6:126506926-126519777 (-)
CAST/EiJ MGP_CASTEiJ_G0030434
 protein coding gene Chr6:132120679-132136997 (-)
CBA/J MGP_CBAJ_G0031016
 protein coding gene Chr6:142174010-142189828 (-)
DBA/2J MGP_DBA2J_G0031173
 protein coding gene Chr6:127138798-127152283 (-)
FVB/NJ MGP_FVBNJ_G0031123
 protein coding gene Chr6:126023847-126042435 (-)
LP/J MGP_LPJ_G0031253
 protein coding gene Chr6:133504499-133521531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031161
 protein coding gene Chr6:146028685-146055466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031824
 protein coding gene Chr6:131765275-131780022 (-)
PWK/PhJ MGP_PWKPhJ_G0030152
 protein coding gene Chr6:125423857-125437491 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029981
 protein coding gene Chr6:129780498-129792125 (-)
WSB/EiJ MGP_WSBEiJ_G0030522
 protein coding gene Chr6:132184316-132200438 (-)



Homology
more
  • Human Ortholog
    KLRC4-KLRK1, KLRC4-KLRK1 readthrough
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRC4-KLRK1, KLRC4-KLRK1 readthrough
  • Links
    NCBI Gene ID: 100528032
    neXtProt AC: NX_P26718
    UniProt: P26718

  • Chr Location
    12p13.2; chr12:10372353-10410146 (-)  GRCh38
  • Human Ortholog
    KLRK1, killer cell lectin like receptor K1
  • Synonyms
    CD314, D12S2489E, KLR, NKG2-D, NKG2D
  • Links
    NCBI Gene ID: 22914
    neXtProt AC: NX_P26718
    UniProt: P26718

  • Chr Location
    12p13.2; chr12:10372353-10391874 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KLRK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in Natural Killer (NK) cell development, diminished NK-mediated cytolysis of tumor cells, and resistance to MCMV infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030149 Ensembl Gene Model | MGI Sequence Detail 13542 C57BL/6J ±  kb
    transcript ENSMUST00000032252 Ensembl | MGI Sequence Detail 1270 Not Applicable  
    polypeptide ENSMUSP00000032252 Ensembl | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 4
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 62
    • Earliest
      J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory