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Dscam Gene Detail
Summary
  • Symbol
    Dscam
  • Name
    DS cell adhesion molecule
  • Synonyms
    4932410A21Rik, Down syndrome cell adhesion molecule
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196281
    NCBI Gene: 13508
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96392040-96971952 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 57.02 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10632 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196281
 protein coding gene Chr16:96388652-96971952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023088
 protein coding gene Chr16:97981864-98600641 (-)
A/J MGP_AJ_G0023056
 protein coding gene Chr16:93347909-93929974 (-)
AKR/J MGP_AKRJ_G0023026
 protein coding gene Chr16:96215977-96817967 (-)
BALB/cJ MGP_BALBcJ_G0023058
 protein coding gene Chr16:93897816-94480168 (-)
C3H/HeJ MGP_C3HHeJ_G0022819
 protein coding gene Chr16:96741935-97349112 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023505
 protein coding gene Chr16:101078332-101699585 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021007
 protein coding gene Chr16:91187043-91764515 (-)
CAST/EiJ MGP_CASTEiJ_G0022339
 protein coding gene Chr16:97541534-98150757 (-)
CBA/J MGP_CBAJ_G0022788
 protein coding gene Chr16:105448491-106090131 (-)
DBA/2J MGP_DBA2J_G0022922
 protein coding gene Chr16:93220377-93795220 (-)
FVB/NJ MGP_FVBNJ_G0022896
 protein coding gene Chr16:92393399-92966375 (-)
LP/J MGP_LPJ_G0022992
 protein coding gene Chr16:97620928-98233119 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022917
 protein coding gene Chr16:109655353-110264070 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023523
 protein coding gene Chr16:96750081-97356815 (-)
PWK/PhJ MGP_PWKPhJ_G0022083
 protein coding gene Chr16:93519107-94105337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021913
 protein coding gene Chr16:96291049-96874303 (-)
WSB/EiJ MGP_WSBEiJ_G0022389
 protein coding gene Chr16:97019874-97626705 (-)



Homology
more
  • Human Ortholog
    DSCAM, DS cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSCAM, DS cell adhesion molecule
  • Synonyms
    CHD2, CHD2-42, CHD2-52
  • Links
    NCBI Gene ID: 1826
    neXtProt AC: NX_O60469
    UniProt: O60469

  • Chr Location
    21q22.2; chr21:40010999-40847158 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 6 alleles in 13 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit background-sensitive perinatal lethality associated with respiratory distress, altered C4 ventral root and pre-inspiratory neuron signaling, and abnormal response to hypercapnia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    161
  • cDNA Data
    15
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050272 Ensembl Gene Model | MGI Sequence Detail 579913 C57BL/6J ±  kb
    transcript ENSMUST00000056102 Ensembl | MGI Sequence Detail 8737 Not Applicable  
    polypeptide ENSMUSP00000056040 Ensembl | MGI Sequence Detail 2013 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 3
      cDNA 16
      Primer pair 2
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926011
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 23
      Diseases 6
      Gene Ontology 11
      Phenotypes 129
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:348024 Touahri Y, et al., Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina. Cell Rep. 2024 Apr 23;43(4):114005
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory